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Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
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The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
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Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
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Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
References
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Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4.
Li Ma,Yu-Ling Liu,Zhizhong Ma,Hong-Liang Dou,Jun-Hui Xu,Jian-Cheng Wang,Xuan Zhang,Qiang Zhang +7 more
TL;DR: RGD-modified SSL loaded with CA4 can be successfully prepared, and the vasculature-targeted liposome system would increase the uptake of HUVECs and improve the therapeutic efficacy of CA4 on CNV compared with the control formulations.
Journal ArticleDOI
Benzaldehyde thiosemicarbazone complexes of platinum: Syntheses, structures and cytotoxic properties
Sarmistha Halder,Piyali Paul,Shie-Ming Peng,Gene-Hsiang Lee,Asama Mukherjee,Sushanta Dutta,Utpal Sanyal,Samaresh Bhattacharya +7 more
TL;DR: The reaction of 4-R-benzaldehyde thiosemicarbazones (denoted in general as H2L-R) with [Pt(PPh3)2Cl2] in the presence of NEt3 afforded a family of organometallic complexes of platinum(II) of the type [PPhPh3)(L)-R] as mentioned in this paper.
Journal ArticleDOI
Usefulness of miriplatin as an anticancer agent for transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma.
Yukinori Imai,Taku Chikayama,Manabu Nakazawa,Kazuhiro Watanabe,Satsuki Ando,Yoshie Mizuno,Kiyoko Yoshino,Kayoko Sugawara,Kazuhiro Hamaoka,Kenji Fujimori,Mie Inao,Nobuaki Nakayama,Masashi Oka,Sumiko Nagoshi,Satoshi Mochida +14 more
TL;DR: Miriplatin is a useful and safe agent for TACE in patients with HCC stage I or II and/or JIS score 0 or 1 only when radiofrequency ablation and liver resection cannot be performed.
Journal ArticleDOI
In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug.
Esther F. A. Brandon,Rolf W. Sparidans,Irma Meijerman,Ignasio Manzanares,Jos H. Beijnen,Jan H.M. Schellens,Jan H.M. Schellens +6 more
TL;DR: Evidence is provided that human CYP3A4 plays a major role in the metabolism of thiocoraline in vitro and that the metabolites formed by CYP are conjugated by the phase II enzymes UGT, ST and GST.
Journal ArticleDOI
Polyaspartamide-Doxorubicin Conjugate as Potential Prodrug for Anticancer Therapy
Chiara Di Meo,Felisa Cilurzo,Mariano Licciardi,Cinzia Scialabba,Rocchina Sabia,Donatella Paolino,Donatella Capitani,Massimo Fresta,Gaetano Giammona,Claudio Villani,Pietro Matricardi +10 more
TL;DR: The features of the PHEA-EDA-DOXO provide a potential protection of the drug from the plasmatic enzymatic degradation and clearance, an improvement of the blood pharmacokinetic parameters and a suitable body biodistribution.