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Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
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Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment
Haimei Chen,Samuel Pazicni,Nancy L. Krett,Richard W. Ahn,James E. Penner-Hahn,Steven T. Rosen,Thomas V. O'Halloran +6 more
TL;DR: Lipid-based carriers have been successfully applied in clinics for improving the therapeutic efficacy of numerous drugs, such as liposomal doxorubicin (Doxil®), mainly via the enhanced permeability and retention (EPR) effects.
Journal ArticleDOI
Antitumor activities of ferrocene compounds
TL;DR: In this paper, data on the antitumor activities of ferrocene compounds and the results concerning the mechanisms of their action published between 1995 and 2010 are discussed and the biomedical aspects of the study of Ferrocene derivatives are briefly analyzed.
Journal ArticleDOI
Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells.
TL;DR: The structure-activity relationship of decursin and its derivatives is as follows: the coumarin structure is required for anti-leukemic activity and the side chain is a determinant of PKC activation and the cytotoxic mechanism in leukemia cells.
Journal ArticleDOI
Ferrocenes as potential anticancer drugs. Facts and hypotheses
V.N. Babin,Yu. A. Belousov,V. I. Borisov,V. V. Gumenyuk,Yu. S. Nekrasov,L. A. Ostrovskaya,I. K. Sviridova,N. S. Sergeeva,A. A. Simenel,L. V. Snegur +9 more
TL;DR: In this paper, the authors analyzed the research data on antitumor effects of a wide range of ferrocene compounds and discussed possible mechanisms of their bioactivities, and proposed promising ways in the design of low-toxicity anticancer Ferrocene-based drugs of new generation.
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The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer
TL;DR: The majority of reviewed studies reported a pain reduction in >50% of patients receiving Dox or Epi, suggesting a substantial palliative effect by their use in metastatic HRPC, suggesting the combination of docetaxel with active agents such as anthracyclines may deserve further clinical investigation.
References
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The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
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Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
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Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
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Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
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Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.