Journal ArticleDOI
Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
Citations
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Journal ArticleDOI
The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
Journal ArticleDOI
Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
Journal ArticleDOI
Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
References
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Journal ArticleDOI
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Colin J. D. Ross,Colin J. D. Ross,Hagit Katzov-Eckert,Hagit Katzov-Eckert,Marie-Pierre Dubé,Beth Brooks,S. Rod Rassekh,Amina Barhdadi,Yassamin Feroz-Zada,Henk Visscher,Henk Visscher,Andrew M.K. Brown,Michael J. Rieder,Paul Rogers,Michael S. Phillips,Bruce Carleton,Bruce Carleton,Michael R. Hayden,Michael R. Hayden +18 more
TL;DR: Association analyses for 220 drug-metabolism genes in genetic susceptibility to cisplatin-induced hearing loss in children are reported and genetic variants in TPMT and COMT are identified associated with cisPlatin- induced hearing Loss in children.
Journal ArticleDOI
Recent trends in targeted anticancer prodrug and conjugate design.
TL;DR: The present review highlights recent trends in prodrug and conjugate rationale and design for cancer treatment and critically analyzed the various approaches that are currently being explored.
Journal ArticleDOI
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.
TL;DR: These studies show that opioids elicit systems‐level adaptations resulting in pain due to descending facilitation, upregulation of spinal dynorphin, and enhanced, evoked release of excitatory transmitters from primary afferents, which indicate the need for the evaluation of the clinical consequences of long‐term opioid administration.
Book ChapterDOI
Plasmid copy number and plasmid stability.
TL;DR: Different methods for the determination of plasmid copy number are described, which include stability during downstream processing, stability after application and stability during storage and shipping.
Journal ArticleDOI
Drug interactions in oncology
TL;DR: A comprehensive overview of drug interactions is provided, with selected examples, between anticancer drugs and over-the-counter or alternative medicines and herbs.