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Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
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Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model
Ina Rattmann,Ina Rattmann,Veronika Kleff,Veronika Kleff,Ursula R. Sorg,Ursula R. Sorg,Walter Bardenheuer,Walter Bardenheuer,Annette Brueckner,Annette Brueckner,Ralf A. Hilger,Ralf A. Hilger,Bertram Opalka,Bertram Opalka,Siegfried Seeber,Siegfried Seeber,Michael Flasshove,Michael Flasshove,T. Moritz,T. Moritz +19 more
TL;DR: CDD is established as a drug-resistance gene highly suitable for myeloprotective purposes, which, given the lack of selection observed in the hands, might best be used in combination with selectable drug- Resistance genes such as MGMT (P140K) or MDR1.
Journal ArticleDOI
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters.
Anna I. Koutsourea,Manolis A. Fousteris,Evagelia S. Arsenou,Athanasios A. Papageorgiou,George Pairas,Sotiris S. Nikolaropoulos +5 more
TL;DR: The synthesis and the in vivo evaluation against leukemias P388 and L1210 of six new alkylating steroidal esters showed increased antileukemic activity and lower toxicity, compared to the 17beta-acetamido-7-keto analogs.
Journal ArticleDOI
A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells
Hideyuki Ikeuchi,Yong-Mo Ahn,Takuya Otokawa,Bunta Watanabe,Lamees Hegazy,Jun Hiratake,Nigel G. J. Richards +6 more
TL;DR: The synthesis and biological activity of two new sulfoximine analogues of 1 are reported, providing further evidence for the idea that hASNS represents a chemotherapeutic target for the treatment of leukemia, and perhaps other cancers, including those of the prostate.
Journal ArticleDOI
Chlorophyll derivative mediated PDT versus methotrexate: an in vitro study using MCF-7 cells.
TL;DR: Compared to MTX, light activated chlorophyll derivative proved to be a better candidate for breast cancer cell toxicity, referring to its higher efficacy at tumour cells killing, safety to normal cells and simple method of extraction.
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Brain metastases in HER2-positive breast cancer: the evolving role of lapatinib
Gianluca Tomasello,Philippe L. Bedard,Evandro de Azambuja,Dominique Lossignol,Daniel Devriendt,Martine Piccart-Gebhart +5 more
TL;DR: The epidemiology, current treatment options and recent advances in the field are reviewed, with a focus on HER2-positive disease and the emerging role of lapatinib for the treatment and prevention of brain metastases.
References
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The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
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Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
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Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
Journal ArticleDOI
Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
Journal ArticleDOI
Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.