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Anti-cancer drugs
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This article is published in Current Pharmaceutical Design.The article was published on 2005-03-31. It has received 882 citations till now. The article focuses on the topics: Introductory Journal Article.read more
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The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
John Ramage,A Ahmed,J Ardill,N.D.S. Bax,David J. Breen,Martyn Caplin,Pippa Corrie,J Davar,Albert Davies,Val Lewington,Tim Meyer,John Newell-Price,Graeme J. Poston,N. Reed,Andrea Rockall,William P. Steward,Rajesh V. Thakker,C. Toubanakis,Juan W. Valle,Caroline S. Verbeke,Ashley B. Grossman +20 more
TL;DR: These guidelines update previous guidance published in 2005 and have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology and others.
Journal ArticleDOI
Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
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Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
References
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L-Asparaginase produced by Streptomyces strain isolated from Egyptian soil: Purification, characterization and evaluation of its anti-tumor
TL;DR: In conclusion, L-asparaginase from S. halstedii showed anti-tumor activity and cytotoxic effect against cancer cell line in vitro and in vitro, and the reduction of tumor size in albino mice may be attributed to the elevation of CAT and SOD activities as well as the diminishing of MDA.
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TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma
TL;DR: TKTL1 as a key prognostic factor may be a novel target for therapy of the patients with ESCC and its underlying biological functions in ESCC are preliminarily elucidated.
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Fenofibrate enhances radiosensitivity of esophageal squamous cell carcinoma by suppressing hypoxia-inducible factor-1α expression.
Yangyang Ge,Jia Liu,Xi Yang,Hongcheng Zhu,Baixia Yang,Kuiling Zhao,Zhijun Wu,Guo-Jian Cheng,Feng Wang,Feng Ni,Qin Ge,Yanguang Yang,Guomei Tai,Xinchen Sun,Jing Cai +14 more
TL;DR: The data suggest that fenofibrate may be a potential radiosensitive drug, and the inhibition of HIF-1α and VEGF expression in ESCC cells contributed to the radiosensitive effect.
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Compounds that Combine Aldose Reductase Inhibitory Activity and Ability to Prevent the Glycation (Glucation and/or Fructation) of Proteins as Putative Pharmacotherapeutic Agents
Vassilis J. Demopoulos,Nazlaa Zaher,Chariklia Zika,Costas Anagnostou,Edouard Mamadou,Polyxeni Alexiou,Ioannis Nicolaou +6 more
TL;DR: The data that will be presented will aim to support the notion that compounds which combine aldose reductase inhibitory activity and ability to prevent the glycation of proteins posses' pharmacotherapeutic potential.
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Antitumor activity of new enantiopure pybox-ruthenium complexes.
Estefanía Menéndez-Pedregal,Josefina Díez,Angel Manteca,Jesús Sánchez,Ana C. Bento,Rósula García-Navas,Faustino Mollinedo,M. Pilar Gamasa,Elena Lastra +8 more
TL;DR: ruthenium complexes containing enantiopure 2,6-bis[4'(R)-phenyloxazolin-2'-il-pyridine] and water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) or N-substituted PTA phosphanes have been synthesized in high yields and fully characterized and their cytotoxic activity against the human cervical cancer HeLa cell line is reported.