Anti-Müllerian hormone-based prediction model for a live birth in assisted reproduction
A. La Marca,Scott M. Nelson,Giovanna Sighinolfi,M. Manno,Enrica Baraldi,Laura Roli,Susanna Xella,Tiziana Marsella,Daniela Tagliasacchi,Roberto D'Amico,Annibale Volpe +10 more
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TLDR
The success of IVF was found to mainly depend on maternal age and serum AMH concentrations, one of the most relevant and valuable markers of ovarian reserve.Abstract:
Prediction of assisted reproduction treatment outcome has been the focus of clinical research for many years, with a variety of prognostic models describing the probability of an ongoing pregnancy or a live birth. This study assessed whether serum anti-Mullerian hormone (AMH) concentrations may be incorporated into a model to enhance the prediction of a live birth in women undergoing their first IVF cycle, by analysing a database containing clinical and laboratory information on IVF cycles carried out between 2005 and 2008 at the Mother-Infant Department of University Hospital, Modena. Logistic regression was used to examine the association of live birth with baseline patient characteristics. Only AMH and age were demonstrated in regression analysis to predict live birth, so a model solely based on these two criteria was generated. The model permitted the identification of live birth with a sensitivity of 79.2% and a specificity of only 44.2%. In the prediction of a live birth following IVF, a distinction, however moderate, can be made between couples with a good and a poor prognosis. The success of IVF was found to mainly depend on maternal age and serum AMH concentrations, one of the most relevant and valuable markers of ovarian reserve.read more
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The physiology and clinical utility of anti-Müllerian hormone in women
Didier Dewailly,Claus Yding Andersen,Adam H. Balen,Frank J. M. Broekmans,Nafi Dilaver,Renato Fanchin,Georg Griesinger,Tom Kelsey,Antonio La Marca,C.B. Lambalk,Helen D. Mason,Scott M. Nelson,Jenny A. Visser,W. Hamish B. Wallace,Richard A. Anderson +14 more
TL;DR: There is a linear relationship between AMH and oocyte yield after ovarian stimulation, which is of value in predicting ovarian hyperstimulation, and the submerged part of the iceberg of follicle growth, i.e. the intrinsic, so-called 'acyclic' ovarian activity is measured.
Journal ArticleDOI
Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications.
TL;DR: AMH is the best current available measure of ovarian reserve for different clinical conditions, and may help to individualize dosing for ovarian stimulation thereby improving the efficiency and safety of IVF and the forecasting of reproductive lifespan, ovarian dysfunction and gonadotoxic cancer treatment or ovarian surgery.
Journal ArticleDOI
Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice
TL;DR: Personalized IVF offers several benefits; it enables clinicians to give women more accurate information on their prognosis thus facilitating counselling especially in cases of extremes of ovarian response.
Journal ArticleDOI
Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach
Simone L. Broer,Jeroen van Disseldorp,Jeroen van Disseldorp,Kimiko A. Broeze,Kimiko A. Broeze,Madeleine Dolleman,Madeleine Dolleman,Brent C. Opmeer,Brent C. Opmeer,Patrick M.M. Bossuyt,Patrick M.M. Bossuyt,Marinus J.C. Eijkemans,Marinus J.C. Eijkemans,Ben W.J. Mol,Ben W.J. Mol,Frank J.M. Broekmans,Frank J.M. Broekmans +16 more
TL;DR: It is demonstrated that AFC and AMH clearly add to age in predicting poor response and ongoing pregnancy after IVF, and the clinical usefulness of ORTs prior to IVF will be limited to the prediction of ovarian response.
Journal ArticleDOI
The predictive accuracy of anti-Müllerian hormone for live birth after assisted conception: a systematic review and meta-analysis of the literature.
TL;DR: AMH, independently of age, has some association with predicting live birth after assisted conception and may be helpful when counselling couples before undergoing fertility treatment, however, its predictive accuracy is poor.
References
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Journal ArticleDOI
Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
TL;DR: In this article, an easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, which are particularly needed for binary, ordinal, and time-to-event outcomes.
Tutorial in biostatistics multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
Kerry L. Lee,Daniel B. Mark +1 more
TL;DR: An easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, which are applicable to all regression models, but are particularly needed for binary, ordinal, and time-to-event outcomes.
Journal ArticleDOI
Internal validation of predictive models: efficiency of some procedures for logistic regression analysis.
Ewout W. Steyerberg,Frank E. Harrell,Gerard J. J. M. Borsboom,Marinus J.C. Eijkemans,Yvonne Vergouwe,J. Dik F. Habbema +5 more
TL;DR: It is concluded that split-sample validation is inefficient, and bootstrapping is recommended for estimation of internal validity of a predictive logistic regression model.
Journal ArticleDOI
World Health Organization Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th ed.
Journal ArticleDOI
The variability of female reproductive ageing
TL;DR: Age at last birth in natural fertility populations, which marks the end of female fertility, shows an identically wide variation as age at menopause, but occurs on average 10 years earlier than this, given the high heritability for age atMenopause.