Journal ArticleDOI
Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era.
TLDR
This review summarizes the recent advances in AMPs development with respect to characteristics, structure‐activity relationships, functions, antimicrobial mechanisms, expression regulation, and applications in food, medicine, and animals.Abstract:
Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely distributed throughout the animal and plant kingdoms. They can protect against a broad array of infection-causing agents, such as bacteria, fungi, parasites, viruses, and tumor cells, and also exhibit immunomodulatory activity. AMPs exert antimicrobial activities primarily through mechanisms involving membrane disruption, so they have a lower likelihood of inducing drug resistance. Extensive studies on the structure-activity relationship have revealed that net charge, hydrophobicity, and amphipathicity are the most important physicochemical and structural determinants endowing AMPs with antimicrobial potency and cell selectivity. This review summarizes the recent advances in AMPs development with respect to characteristics, structure-activity relationships, functions, antimicrobial mechanisms, expression regulation, and applications in food, medicine, and animals.read more
Citations
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Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
TL;DR: This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved.
Journal ArticleDOI
DRAMP 2.0, an updated data repository of antimicrobial peptides
Xinyue Kang,Fanyi Dong,Cheng Shi,Shicai Liu,Jian Sun,Jiaxin Chen,Haiqi Li,Hanmei Xu,Xingzhen Lao,Heng Zheng +9 more
TL;DR: Several AMPs in clinical trials are described, including their properties, indications and clinicaltrials.gov identifiers, to provide the applications of DRAMP in the development of AMPs.
Journal ArticleDOI
Antimicrobial peptides: mechanism of action, activity and clinical potential.
Qiyu Zhang,Zhi-Bin Yan,Yueming Meng,Xiang-Yu Hong,Gang Shao,Jun-Jie Ma,Xurui Cheng,Jun Liu,Jian Kang,Jian Kang,Caiyun Fu +10 more
TL;DR: Antimicrobial peptides (AMPs) as mentioned in this paper are an excellent candidate to overcome antibiotic resistance, they demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.
Journal ArticleDOI
Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications
Peng Tan,Huiyang Fu,Xi Ma +2 more
TL;DR: The progress in the design and optimization strategies of AMPs were reviewed, which lay a theoretical foundation for the development of peptide-based antimicrobial nanomaterials and provided more effective antibiotic alternatives.
Journal ArticleDOI
Antiviral activity of Piscidin 1 against pseudorabies virus both in vitro and in vivo
Han Hu,Han Hu,Nan Guo,Shuhua Chen,Xiaozhen Guo,Xiaoli Liu,Shiyi Ye,Qingqing Chai,Yang Wang,Binlei Liu,Qigai He +10 more
TL;DR: In vitro and in vivo experiments indicate that piscidin has antiviral activity against PRV and can reduce the mortality of mice infected with PRV.
References
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Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study
Yiyun Liu,Yang Wang,Timothy R. Walsh,Ling-Xian Yi,Rong Zhang,James Spencer,Yohei Doi,Guo-Bao Tian,Baolei Dong,Xianhui Huang,Lin-Feng Yu,Danxia Gu,Hongwei Ren,Xiaojie Chen,Luchao Lv,Dandan He,Hongwei Zhou,Zi-sen Liang,Jian-Hua Liu,Jianzhong Shen +19 more
TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.
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Global trends in antimicrobial use in food animals
Thomas P. Van Boeckel,Charles H. Brower,Marius Gilbert,Bryan Bt Grenfell,Bryan Bt Grenfell,Simon A. Levin,Timothy P. Robinson,Aude Teillant,Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan +10 more
TL;DR: The first global map (228 countries) of antibiotic consumption in livestock is presented and it is projected that antimicrobial consumption will rise by 67% by 2030, and nearly double in Brazil, Russia, India, China, and South Africa.
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Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.
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MEMBRANE PROTEIN FOLDING AND STABILITY: Physical Principles
TL;DR: A coherent thermodynamic formalism for determining and describing the energetics of peptide-bilayer interactions and a review of the properties of the environment of membrane proteins--the bilayer milieu are reviewed.