Journal ArticleDOI
Applications for site-directed molecular imaging agents coupled with drug delivery potential.
Hui Wang,Xiaoyuan Chen +1 more
TLDR
This review article summarizes the synthesis and characterization of various biomaterials that carry targeting motifs, imaging tags and therapeutic agents as theragnostics for imaging guided drug delivery.Abstract:
Molecular imaging allows non-invasive characterization and quantification of biological processes at cellular and molecular level. Such technologies make it possible to enhance our understanding of drug activity and pharmokinetic properties, and therefore aid decisions to select candidates that are most likely to benefit from targeted drug therapy. Targeted DDSs are nanometer-sized carrier materials designed for improving the biodistribution of systemically applied (chemo-)therapeutics by strictly localizing its pharmacological activity to the site or organ of action. The parallel development of molecular imaging and targeted drug delivery offers great challenges and opportunities for a single multifunctional platform technology, combining targeted motif, therapeutic agents and imaging agents for imaging guided drug delivery. This review article summarizes the synthesis and characterization of various biomaterials that carry targeting motifs, imaging tags and therapeutic agents as theragnostics.read more
Citations
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Journal ArticleDOI
Direct fluorescence monitoring of the delivery and cellular uptake of a cancer-targeted RGD peptide-appended naphthalimide theragnostic prodrug.
Min Hee Lee,Jin Young Kim,Ji Hye Han,Sankarprasad Bhuniya,Jonathan L. Sessler,Jonathan L. Sessler,Chulhun Kang,Jong Seung Kim +7 more
TL;DR: The present drug delivery system (DDS) could represent a new approach to so-called theragnostic agent development, wherein both a therapeutic effect and drug uptake-related imaging information are produced and can be readily monitored at the subcellular level.
Journal ArticleDOI
Disulfide-based multifunctional conjugates for targeted theranostic drug delivery.
TL;DR: It is proposed that disulfide-based cancer-targeting theranostics may have a role to play in advancing drug discovery efforts, as well as improving the understanding of cellular uptake and drug release mechanisms.
Journal ArticleDOI
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.
Ashwin Bhirde,Sachin Patel,Alioscka A. Sousa,Vyomesh Patel,Alfredo A. Molinolo,Youngmi Ji,Richard D. Leapman,J. Silvio Gutkind,James F. Rusling,James F. Rusling +9 more
TL;DR: PEG-SWCNTs form more highly dispersed delivery vehicles that, when loaded with both cisplatin and EGF, inhibit growth of squamous cell tumors.
Journal ArticleDOI
DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy
Tao Chen,Cuichen Wu,Elizabeth Jiménez,Zhi Zhu,Joshua G. Dajac,Mingxu You,Da Han,Xiaobing Zhang,Weihong Tan,Weihong Tan +9 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about concrete mechanical properties of E-modulus in the response of the immune system to EMT.
Journal ArticleDOI
Nanotechnology and nanomedicine: going small means aiming big.
TL;DR: This review provides an integrated overview of application of nanotechnology based molecular diagnostics and drug delivery in the development of nanomedicine and ultimately personalized medicine.
References
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
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The dawning era of polymer therapeutics
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The fluorescent toolbox for assessing protein location and function
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