Journal ArticleDOI
Applications of a DNA-electrochemical biosensor
TLDR
This review discusses recent advances on the design and applications of DNA-electrochemical biosensors that use DNA direct electrochemistry as a detection platform and describes new bottom up immobilisation procedures of self-assembled nanostructures based on DNA single- and double-stranded, G-quadruplex, and i-motif configurations.Abstract:
As carrier of genetic information, DNA is one of the most important intracellular targets that undergo modification and damage upon interaction with endogenous and exogenous factors. DNA is an excellent biomaterial for the construction of new devices, in nanotechnology and biosensor technology, for evaluation of DNA interaction with a broad range of chemical compounds and biomolecules, essential from a biological and a medical point of view. This review discusses recent advances on the design and applications of DNA-electrochemical biosensors that use DNA direct electrochemistry as a detection platform. AFM and voltammetric characterization of new bottom up immobilisation procedures of self-assembled nanostructures based on DNA single- and double-stranded, G-quadruplex, and i-motif configurations are presented, relevant for the development of new DNA-electrochemical biosensor devices. The applications of DNA-electrochemical biosensors, for the label-free detection of interactions with proteins, pharmaceutical compounds, metal ions and metal complexes, pollutants, free radicals, and electromagnetic radiation, were revisited.read more
Citations
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Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors.
TL;DR: A series of substituted pyrazole compounds were synthesized and their structure was characterized by IR, NMR, and Mass analysis and emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms and acetylcholinesterase enzymes with Ki values in the range of 1.23-22.65 ± 5.36 µM.
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Fabrication strategies, sensing modes and analytical applications of ratiometric electrochemical biosensors
TL;DR: This review systematically summarize the fabrication strategies, sensing modes and analytical applications of RECBSs, which exhibit a significant potential to improve the accuracy and sensitivity in electrochemical sensing applications.
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Review—Measurement and Analysis of Cancer Biomarkers Based on Electrochemical Biosensors
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Voltammetric determination of metal ions beyond mercury electrodes. A review.
TL;DR: The present review critically summarizes and discusses the progress made since 2010 in the development and application of new electrodes for the analysis of metals and metalloids.
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Aptasensors as the future of antibiotics test kits-a case study of the aptamer application in the chloramphenicol detection
TL;DR: In the present review, the recent achievements of the accessible aptasensors for qualitative detection and quantitative determination of chloramphenicol as a candidate of the antibiotics are summarized and some results are presented based on the advantages and disadvantages to achieve a promising perspective for designing the novel antibiotics test kits.
References
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Journal ArticleDOI
Electrochemistry of nucleic acids.
Emil Paleček,Martin Bartošík +1 more
TL;DR: Oscillographic polarography, at controlled alternating current, was used in the electrochemical analysis of nucleic acids and briefly summarizes some properties of the elimination voltammetry with linear scan (EVLS) method.
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Programming the detection limits of biosensors through controlled nanostructuring
TL;DR: It is shown that by nanostructuring the sensing electrodes, it is possible to create nucleic acid sensors that have a broad range of sensitivities and that are capable of rapid analysis.
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Voltammetric determination of all DNA nucleotides.
TL;DR: The voltammetric oxidation of all deoxyribonucleic acid (DNA) monophosphate nucleotides is investigated for the first time over a wide pH range by differential pulse voltammetry with a glassy carbon electrode.
Journal ArticleDOI
Past, present and future of nucleic acids electrochemistry
TL;DR: A great progress in the development of electrochemical sensors for DNA hybridization and DNA damage achieved in recent years suggests that these sensors may soon become important tools in medicine and other areas of practical life of the 21st century.
Journal ArticleDOI
Hydroxyl radicals electrochemically generated in situ on a boron-doped diamond electrode
Teodor Adrian Enache,Ana-Maria Chiorcea-Paquim,Orlando Fatibello-Filho,Ana Maria Oliveira-Brett +3 more
TL;DR: In this paper, the hydroxyl radicals generated in situ on a boron-doped diamond (BDD) electrode have been investigated for the first time in different electrolyte media, over the whole pH range between 1 and 11.