Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
TLDR
This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-Penetrating Peptide based delivery.Abstract:
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.read more
Citations
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Journal ArticleDOI
Cell-Penetrating Peptides: From Basic Research to Clinics
TL;DR: In this article, cell-penetrating peptides (CPPs) have been used to increase medicament concentrations in areas that are difficult to access, which can transport into the cell a wide variety of biologically active conjugates.
Journal ArticleDOI
Evaluation of the use of therapeutic peptides for cancer treatment
TL;DR: In this review, strategies used to overcome peptide limitations and to enhance their therapeutic effect will be compared and the use of short cell permeable peptides that interfere and inhibit protein-protein interactions will be evaluated.
Journal ArticleDOI
Cell penetrating peptides: A concise review with emphasis on biomedical applications.
TL;DR: Owing to the ability of CPPs to transport across cellular membrane, they can employ as an appropriate carrier for various cargos include nucleic acid, proteins, SiRNA, therapeutic agents, nanoparticles and so on.
Journal ArticleDOI
Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides.
TL;DR: This review focuses on peptides as carriers and targeting moieties in drug‐peptide covalent conjugates and summarizes the most recent literature examples where CPPs on their own or CPP's together with TTPs have been conjugated to anticancer drugs such as Doxorubicin, Methotrexate, Paclitaxel, Chlorambucil etc.
Patent
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
TL;DR: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them as discussed by the authors, as well as a detailed discussion of their properties.
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Cell penetrating peptides
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Transvascular delivery of small interfering RNA to the central nervous system
Priti Kumar,Haoquan Wu,Jodi L. McBride,Kyeong Eun Jung,Moon Hee Kim,Beverly L. Davidson,Sang-Kyung Lee,Premlata Shankar,N. Manjunath +8 more
TL;DR: RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier and afforded robust protection against fatal viral encephalitis in mice.
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