Journal ArticleDOI
Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides.
TLDR
This review focuses on peptides as carriers and targeting moieties in drug‐peptide covalent conjugates and summarizes the most recent literature examples where CPPs on their own or CPP's together with TTPs have been conjugated to anticancer drugs such as Doxorubicin, Methotrexate, Paclitaxel, Chlorambucil etc.About:
This article is published in Journal of Controlled Release.The article was published on 2017-03-28. It has received 202 citations till now. The article focuses on the topics: Targeted drug delivery & Cell-penetrating peptide.read more
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Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review.
Thiruganesh Ramasamy,Hima Bindu Ruttala,Biki Gupta,Bijay Kumar Poudel,Han-Gon Choi,Chul Soon Yong,Jong Oh Kim +6 more
TL;DR: This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10years and highlights the next generation nanomedicine strategies based on this novel chemistry.
Journal ArticleDOI
Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review.
Muhammad Kashif Riaz,Muhammad Adil Riaz,Xue Zhang,Congcong Lin,Ka Hong Wong,Xiaoyu Chen,Ge Zhang,Aiping Lu,Zhijun Yang +8 more
TL;DR: Information is reviewed about the strategies for targeting of liposomes to solid tumors along with the possible targets in cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature.
Journal ArticleDOI
Electrospun polymer micro/nanofibers as pharmaceutical repositories for healthcare.
TL;DR: The basic principles of electrospinning, and the mechanisms and applications of Electrospun micro/nanofibers for delivery of small molecule drugs, proteins, and nucleic acids in the healthcare field are introduced.
Journal ArticleDOI
Rational Design of Nanocarriers for Intracellular Protein Delivery.
Xiaofei Qin,Changmin Yu,Jing Wei,Lin Li,Chengwu Zhang,Qiong Wu,Jinhua Liu,Shao Q. Yao,Wei Huang,Wei Huang +9 more
TL;DR: In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized and the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented.
Journal ArticleDOI
Cell penetrating peptides: the potent multi-cargo intracellular carriers.
TL;DR: Generally, the efficiency of CPPs was suitable to penetrate the cell membrane and deliver different cargos to specific intracellular sites and there are some disadvantages for C PPs including short half-life in blood, and nonspecific CPP-mediated delivery to normal tissue.
References
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Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
Journal ArticleDOI
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
TL;DR: Foreign DNA fragments can be inserted into filamentous phage gene III to create a fusion protein with the foreign sequence in the middle that is incorporated into the virion, which retains infectivity and displays the foreign amino acids in immunologically accessible form.
Journal ArticleDOI
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
TL;DR: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl- L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronsectin and present in at least five other proteins.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.
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