Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease
TLDR
The hypothesis that Parkinson’s disease could begin in the gut is supported, with a focus on how food-based therapies might then have an influence on PD and could ameliorate non-motor as well as motor symptoms.Abstract:
Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial role in the gut–brain axis, which is a bidirectional communication between the central nervous system and the enteric nervous system. Diet can affect the microbiota composition, impacting gut–brain axis functionality. Gut microbiome restoration through probiotics, prebiotics, synbiotics or other dietary means could have the potential to slow PD progression. In this review, we will discuss the influence of diet on the bidirectional communication between gut and brain, thus supporting the hypothesis that this disorder could begin in the gut. We also focus on how food-based therapies might then have an influence on PD and could ameliorate non-motor as well as motor symptoms.read more
Citations
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The Therapeutic Role of Ketogenic Diet in Neurological Disorders
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The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment
Angelica Varesi,Lucrezia Irene Maria Campagnoli,Foroogh Fahmideh,E Pierella,Marcello Romeo,Giovanni Ricevuti,Marchesi Nicoletta,Salvatore Chirumbolo,Alessia Pascale +8 more
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Gut microbiota, pathogenic proteins and neurodegenerative diseases
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Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease
TL;DR: The current literature on the nutritive patterns and inflammatory markers as a predictor for early detection of Parkinson’s disease is reviewed to foster the detection of early nutritious patterns and preclinical biomarkers to potentially alter PD development and progression.
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Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art
Ana Beatriz Ramalho Leite Silva,RPd Oliveira,Guilherme Pinheiro Diógenes,Marina Feitosa de Castro Aguiar,Camilla Costa Sallem,Micael Porto Portela Lima,Luciano Barroso de Albuquerque Filho,Sara Diógenes Peixoto de Medeiros,Lucas Lopes Penido de Mendonça,Paulo Cesar de Santiago Filho,Diogo Pasquali Nones,Pâmella Cardoso,Michelle Zonkowski Ribas,Stéfani Lara Galvão,G. M. F. Gomes,Amanda Rebouças Bezerra de Menezes,Nayla Lima dos Santos,Victor Monteiro Mororó,Fairane Sousa Duarte,Júlio César Claudino dos Santos +19 more
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