Journal ArticleDOI
Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females.
TLDR
The present study suggests that the functional COMT Val158Met genetic polymorphism contributes to individual differences in the personality traits novelty seeking and reward dependence.Abstract:
Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Vread more
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Psychosocial Stress and Psychosis. A Review of the Neurobiological Mechanisms and the Evidence for Gene-Stress Interaction
Ruud van Winkel,Ruud van Winkel,Nicholas C. Stefanis,Nicholas C. Stefanis,Inez Myin-Germeys,Inez Myin-Germeys +5 more
TL;DR: Evidence is presented suggesting that psychosocial stress may increase risk for psychosis, especially in the case of cumulative exposure, and that polymorphisms within the catechol-O-methyltransferase and brain-derived neurotrophic factor genes may interact with psychossocial stress in the development of psychosis.
Journal ArticleDOI
Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data.
TL;DR: The DRD4 gene may be associated with measures of novelty seeking and impulsivity but not extraversion, and the association of the C-521T variant with these measures, if genuine, may account for up to 3% of phenotypic variance.
Journal ArticleDOI
Variation in dopamine genes influences responsivity of the human reward system
TL;DR: The results indicate that genetically influenced variations in dopamine transmission modulate the response of brain regions involved in anticipation and reception of rewards and suggest that these responses may contribute to individual differences in reward-seeking behavior and in predisposition to neuropsychiatric disorders.
Journal ArticleDOI
The molecular genetic architecture of human personality: beyond self-report questionnaires
TL;DR: Molecular genetic studies of personality began with two high impact papers in 1996 that showed provisional associations between the dopamine DRD4 exon III repeat region and Novelty Seeking/Extraversion and an investigation linking Neuroticism/Harm Avoidance with the serotonin transporter promoter region polymorphism (5-HTTLPR).
Journal ArticleDOI
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Michael Berk,Michael Berk,Seetal Dodd,Márcia Kauer-Sant'Anna,Gin S Malhi,Michel Bourin,Flávio Kapczinski,Trevor R. Norman +7 more
TL;DR: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model, but there is a wealth of converging data on the role of dopamine, and the possibility of a dopamine hypothesis for bipolar disorder is examined.
References
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Journal ArticleDOI
A systematic method for clinical description and classification of personality variants: A proposal.
TL;DR: In this article, a method for clinical description and classification of both normal and abnormal personality variants is proposed based on a general biosocial theory of personality, and three dimensions of personality are defined in terms of the basic stimulus-response characteristics of novelty seeking, harm avoidance and reward dependence.
Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.
Journal ArticleDOI
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking.
Richard P. Ebstein,Olga Novick,Roberto Umansky,Beatrice Priel,Yamima Osher,Darren Blaine,Estelle R. Bennett,Lubov Nemanov,Miri Katz,Robert H. Belmaker +9 more
TL;DR: This work provides the first replicated association between a specific genetic locus involved in neuro-transmission and a normal personality trait, the 7 repeat allele in the locus for the D4 dopamine receptor gene (D4DR).
Journal ArticleDOI
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.
Timo Lotta,Jukka Vidgren,Carola Tilgmann,I. Ulmanen,Krister Melén,Ilkka Julkunen,Jyrki Taskinen +6 more
TL;DR: Comparison of velocity parameters, substrate selectivity, and regioselectivity of the methylation of both enzyme forms, and a revised mechanism for the reaction cycle are discussed.