Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol SNAr chemistry
Elaine A. Qian,Alex I. Wixtrom,Jonathan C. Axtell,Azin Saebi,Dahee Jung,Pavel Rehak,Yanxiao Han,Elamar Hakim Moully,Daniel Mosallaei,Sylvia Chow,Marco S. Messina,Jing Yang Wang,A. Timothy Royappa,Arnold L. Rheingold,Heather D. Maynard,Petr Král,Alexander M. Spokoyny +16 more
Reads0
Chats0
TLDR
A new approach to form atomically precise and highly tunable hybrid nanomolecules with well-defined three-dimensionality is reported, which allows the rapid generation of precise molecular assemblies for investigating multivalent interactions.Abstract:
The majority of biomolecules are intrinsically atomically precise, an important characteristic that enables rational engineering of their recognition and binding properties. However, imparting a similar precision to hybrid nanoparticles has been challenging because of the inherent limitations of existing chemical methods and building blocks. Here we report a new approach to form atomically precise and highly tunable hybrid nanomolecules with well-defined three-dimensionality. Perfunctionalization of atomically precise clusters with pentafluoroaryl-terminated linkers produces size-tunable rigid cluster nanomolecules. These species are amenable to facile modification with a variety of thiol-containing molecules and macromolecules. Assembly proceeds at room temperature within hours under mild conditions, and the resulting nanomolecules exhibit high stabilities because of their full covalency. We further demonstrate how these nanomolecules grafted with saccharides can exhibit dramatically improved binding affinity towards a protein. Ultimately, the developed strategy allows the rapid generation of precise molecular assemblies to investigate multivalent interactions.read more
Citations
More filters
Journal ArticleDOI
Aggregation-Induced Emission: New Vistas at the Aggregate Level
TL;DR: This review focuses on the new properties of materials endowed by molecular aggregates beyond the microscopic molecular level and hopes this review will inspire more research into molecular ensembles at/beyond mesoscale level and lead to the significant progresses in material science, biological science, etc.
Journal ArticleDOI
The influence of the molecular packing on the room temperature phosphorescence of purely organic luminogens.
Jie Yang,Xu Zhen,Bin Wang,Xuming Gao,Zichun Ren,Jiaqiang Wang,Yujun Xie,Jian-Rong Li,Qian Peng,Kanyi Pu,Zhen Li +10 more
TL;DR: It is found that strong π–π interactions in solid state can promote the persistent RTP and CS-CF3 shows the unique photo-induced phosphorescence in response to the changes in molecular packing, further confirming the key influence of the molecular packing on the RTP property.
Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine
TL;DR: In this paper, the use of mesoporous silica nanoparticles (MSNPs) has been investigated for the delivery of bioactive agents within living tissue, where the payload "cargo" molecules can be stored within this robust domain, which is stable to a wide range of chemical conditions.
Journal ArticleDOI
Aggregation-induced emission: fundamental understanding and future developments
Yuncong Chen,Yuncong Chen,Jacky Wing Yip Lam,Ryan T. K. Kwok,Bin Liu,Ben Zhong Tang,Ben Zhong Tang +6 more
TL;DR: In-depth discussion on recent progress of fundamental understanding of AIE mechanisms, identifying the existing challenges and opportunities for future developments.
References
More filters
Journal ArticleDOI
A short history of SHELX
TL;DR: This paper could serve as a general literature citation when one or more of the open-source SH ELX programs (and the Bruker AXS version SHELXTL) are employed in the course of a crystal-structure determination.
Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems
TL;DR: An N⋅log(N) method for evaluating electrostatic energies and forces of large periodic systems is presented based on interpolation of the reciprocal space Ewald sums and evaluation of the resulting convolutions using fast Fourier transforms.
Journal ArticleDOI
OLEX2: a complete structure solution, refinement and analysis program
TL;DR: OLEX2 seamlessly links all aspects of the structure solution, refinement and publication process and presents them in a single workflow-driven package, with the ultimate goal of producing an application which will be useful to both chemists and crystallographers.
Journal ArticleDOI
SHELXT - Integrated space-group and crystal- structure determination
TL;DR: This work automates routine small-molecule structure determination starting from single-crystal reflection data, the Laue group and a reasonable guess as to which elements might be present.