Journal ArticleDOI
Awaji criteria improves the diagnostic sensitivity in amyotrophic lateral sclerosis: A systematic review using individual patient data.
Nimeshan Geevasinga,Clement T. Loy,Parvathi Menon,Mamede de Carvalho,Michael Swash,Michael Swash,Maarten Schrooten,Philip Van Damme,Malgorzata Gawel,Masahiro Sonoo,Mana Higashihara,Yu-ichi Noto,Satoshi Kuwabara,Matthew C. Kiernan,Petra Macaskill,Steve Vucic +15 more
TLDR
The updated Awaji criteria enhanced the diagnostic sensitivity in limb-onset ALS and should be considered in clinical practice and future therapeutic trials.About:
This article is published in Clinical Neurophysiology.The article was published on 2016-07-01. It has received 68 citations till now.read more
Citations
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Journal ArticleDOI
Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria
Michael J. Strong,Sharon Abrahams,Laura H. Goldstein,Susan C. Woolley,Paula M. McLaughlin,Julie S. Snowden,Eneida Mioshi,Angie Roberts-South,Michael Benatar,Tibor Hortobágyi,Jeffrey Rosenfeld,Vincenzo Silani,Paul G. Ince,Martin R Turner +13 more
TL;DR: These revised consensus criteria expand upon those of 2009 and embrace the concept of the frontotemporal spectrum disorder of ALS (ALS-FTSD), which is a re-conceptualisation that neuropsychological deficits in ALS fall along a spectrum.
Journal ArticleDOI
Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques.
TL;DR: An overview of key advances in the understanding of ALS pathophysiology and diagnosis is provided, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.
Journal ArticleDOI
Lower motor neuron dysfunction in ALS.
TL;DR: In the motor system there is a complex interplay between cortical structures and spinal cord lower motor neurons (LMN). In this system both inhibitory and excitatory neurons have relevant roles as discussed by the authors.
Journal ArticleDOI
Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis.
Andrew Hannaford,Nathan Pavey,Mehdi van den Bos,Nimeshan Geevasinga,Parvathi Menon,Jeremy M. Shefner,Matthew C. Kiernan,Steve Vucic +7 more
TL;DR: In this article, the diagnostic utility of the recently proposed Gold Coast criteria was determined in ALS, with benefits evident in bulbar and limb onset disease patients, as well as atypical phenotypes.
Journal ArticleDOI
Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study
Ryuji Kaji,Takashi Imai,Yasuo Iwasaki,Koichi Okamoto,Masanori Nakagawa,Yasuo Ohashi,Takao Takase,Takahisa Hanada,Hiroki Shimizu,Kunio Tashiro,Shigeki Kuzuhara +10 more
TL;DR: Although ultra-high-dose methylcobalamin did not show significant efficacy in the whole cohort, this treatment may prolong survival and retard symptomatic progression without major side effects if started early.
References
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Journal ArticleDOI
El Escorial revisited : revised criteria for the diagnosis of amyotrophic lateral sclerosis
TL;DR: The criteria described below represent the result of a three-day workshop, convened at Airlie Conference Center, Warrenton, Virginia on 2–4 April, 1998 by the World Federation of Neurology Research Committee on Motor Neuron Diseases, and are placed on the WFN ALS website.
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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
TL;DR: In this article, an evidence-based quality assessment tool called QUADAS was proposed to assess the quality of primary studies of diagnostic accuracy, based on the results of three previously conducted reviews of the diagnostic literature.
Journal ArticleDOI
SeminarAmyotrophic lateral sclerosis
Matthew C Kiernan,Steve Vucic,Benjamin C. Cheah,Martin R Turner,Andrew Eisen,Orla Hardiman,James R. Burrell,Margaret C. Zoing +7 more
TL;DR: This paper summarized current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same, focusing on the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.
of amyotrophic lateral sclerosis
John D. Lee,Nur A. Kamaruzaman,Jenny Nt Fung,Stephen Maxwell Taylor,Bradley J. Turner,Julie D. Atkin,Trent M. Woodruff,Peter G. Noakes +7 more
TL;DR: This Seminar summarises current concepts about the origin of the disease, what predisposes patients to develop the disorder, and why all cases of ALS are not the same.
Journal ArticleDOI
Electrodiagnostic criteria for diagnosis of ALS.
Mamede de Carvalho,Reinhard Dengler,Andrew Eisen,John D. England,Ryuji Kaji,Jun Kimura,Kerry R. Mills,Hiroshi Mitsumoto,Hiroyuki Nodera,Jeremy M. Shefner,Michael Swash +10 more
TL;DR: The utility of needle EMG and nerve conduction studies was affirmed and electrophysiological evidence for chronic neurogenic change should be taken as equivalent to clinical information in the recognition of involvement of individual muscles in a limb.