Journal ArticleDOI
Bariatric Surgery Impact on Reproductive Hormones, Semen Analysis, and Sperm DNA Fragmentation in Men with Severe Obesity: Prospective Study
Guilherme J. A. Wood,Bruno Camargo Tiseo,Davi V. Paluello,Hamilton de Martin,Marco Aurelio Santo,William C. Nahas,Miguel Srougi,Marcello Cocuzza +7 more
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TLDR
It is found that bariatric surgery results in improvements in reproductive hormone levels and SDF after 6-month follow-up, and no changes in the variables studied were observed in non-operated patients.Abstract:
Growing evidence in the literature suggests that obesity is capable of altering reproductive hormone levels and male fertility. Effects on classic semen parameters and sperm DNA fragmentation (SDF), however, have not been properly established. Additionally, the impact of bariatric surgery (BS) on those parameters is still controversial. In Phase 1, 42 patients with obesity and 32 fertile controls were submitted to reproductive hormone evaluation, semen analysis, and SDF testing. In Phase 2, patients with obesity were submitted to BS or clinical follow-up and were invited to 6-month revaluation. Phase 1: Men with obesity have higher levels of estradiol, LH, and FSH and lower levels of total testosterone (TT) when compared with eutrophic fertile men. Additionally, they present worse semen parameters, with reduction in ejaculated volume and sperm concentration, worse sperm motility and morphology, and higher SDF. Phase 2: 32 patients returned to revaluation. Eighteen were submitted to BS (group S) and 14 were not submitted to any specific therapeutic regimen (group NS). In group S, TT more than doubled after surgery (294.5 to 604 ng/dL, p < 0.0001). Worsening of sperm concentration and total ejaculated sperm count were also noticed, and 2 patients became azoospermic after BS. SDF, however, improved after the procedure. No changes in the variables studied were observed in non-operated patients. In this prospective study, we have found that BS results in improvements in reproductive hormone levels and SDF after 6-month follow-up. Sperm concentration, however, reduced after the procedure.read more
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Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Álvaro Hernáez,Álvaro Hernáez,Álvaro Hernáez,Tormod Rogne,Tormod Rogne,Karoline H Skåra,Siri E. Håberg,Christian M. Page,Christian M. Page,Abigail Fraser,Stephen Burgess,Debbie A Lawlor,Maria C. Magnus,Maria C. Magnus +13 more
TL;DR: In this paper, a J-shaped relationship between BMI and subfertility in both sexes, when using both a standard multivariable regression and Mendelian randomization (MR) analysis was observed.
Journal ArticleDOI
Effect of bariatric surgery on in vitro fertilization in infertile men with obesity.
Nunzio Velotti,Fatima Domenica Elisa De Palma,Fatima Domenica Elisa De Palma,Loredana Maria Sosa Fernandez,Michele Manigrasso,Giuseppe Galloro,Antonio Vitiello,Giovanna Berardi,Marco Milone,Giovanni Domenico De Palma,Mario Musella +10 more
TL;DR: In this article, the effect of bariatric surgery on in vitro fertilization (IVF) outcomes in a cohort of men with morbid obesity who underwent sleeve gastrectomy (SG) was investigated.
Journal ArticleDOI
Effect of bariatric surgery on endogenous sex hormones and sex hormone-binding globulin levels: a systematic review and meta-analysis.
Mohammad Reza Emami,Maryam Safabakhsh,Masoud Khorshidi,Omid Moradi Moghaddam,Shimels Hussien Mohammed,Meysam Zarezadeh,Shahab Alizadeh +6 more
TL;DR: In this paper, a systematic review and meta-analysis was conducted to examine the magnitude of possible changes in levels of sex hormones following bariatric surgery, and the results revealed that BS caused a significant increase in luteinizing hormone (LH), follicular stimulating hormone (FSH), total testosterone (TT), and sex hormone binding globulin (SHBG) levels and conversely, decreased dehydroepiandrosterone (DHEA) and estradiol (E2) levels in males.
Journal ArticleDOI
Sperm DNA integrity and male infertility: a narrative review and guide for the reproductive physicians
Ala’a N. Farkouh,Gianmaria Salvio,Shinnosuke Kuroda,Ramadan A Saleh,Paraskevi Vogiatzi,Ashok Agarwal +5 more
TL;DR: The sum of literature provides evidence of detrimental effects of high SDF on both natural and assisted fertility outcomes, and standardization of the techniques used for assessment of SDF and their incorporation into the work up of infertile couples may have significant implications on the future management of a selected category of infERTile men with high S DF.
Journal ArticleDOI
Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile
Felipe Pioner Machado,Ernani Luis Rhoden,Sérgio Ricardo Pioner,Graziele Halmenschlager,Luis Vinicius Bastos de Souza,Bruno Chao Lisot,Igor Pires Drachler +6 more
TL;DR: Machado et al. as mentioned in this paper evaluated the effect of weight loss through bariatric surgery on sexual function, low T symptoms, and hormonal profiles in obese men, and found that significant weight loss improves erectile function, hormonal profile, and symptoms of T deficiency.
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TL;DR: The global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013 is estimated using a spatiotemporal Gaussian process regression model to estimate prevalence with 95% uncertainty intervals (UIs).
Journal ArticleDOI
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
TL;DR: The FT value, obtained by calculation from T and SHBG as determined by immunoassay, appears to be a rapid, simple, and reliable index of bioavailable T, comparable to AFTC and suitable for clinical routine, except in pregnancy.