Journal ArticleDOI
Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562.
Devalraju Sreekanth,M.K. Arunasree,Karnati R. Roy,T. Chandramohan Reddy,Gorla V. Reddy,Pallu Reddanna +5 more
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TLDR
It is demonstrated that betanin induces apoptosis in K562 cells through the intrinsic pathway and is mediated by the release of cytochrome c from mitochondria into the cytosol, and PARP cleavage.About:
This article is published in Phytomedicine.The article was published on 2007-11-05. It has received 211 citations till now. The article focuses on the topics: Betanin & Apoptosis.read more
Citations
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Journal ArticleDOI
Betacyanins and Anthocyanins in Pulp and Peel of Red Pitaya (Hylocereus polyrhizus cv. Jindu), Inhibition of Oxidative Stress, Lipid Reducing, and Cytotoxic Effects
TL;DR: In this article , the red pitaya of Chinese origin was determined for its in vitro efficacy, where the fruit extracts were evaluated based on the selected antioxidative properties, lipid-reducing capacity, and cytotoxicity.
Dissertation
Mise en évidence de la diversité des populations de cactus (Opuntia spp.) au Maroc et de la modulation du métabolisme lipidique par des extraits naturels et de phytostérols issues de cactus ou d'huile d'Argan dans les cellules microgliales BV2
TL;DR: L’objectif des travaux de cette these concerne la caracterisation du germoplasme marocain du cactus Opuntia, concurrence d’une grande diversite genetique intra-especes (varietes) et inter-esPEces chez le cactus au Maroc.
Betalaínas: das Cores das Beterrabas à Fluorescência das Flores
Letícia Christina Pires Gonçalves,Antonio Carlos Marcato,Ana Clara B. Rodrigues,Ana Paula Eskildsen Pagano,Barbara Coelho de Freitas,Caroline O. Machado,Karina K. Nakashima,Larissa Cerrato Esteves,Nathana Barbosa Lopes,Erick Leite Bastos +9 more
TL;DR: A diversidade de cores encontradas na flora resulta da interacao de algumas poucas classes of pigmentos com a luz Betalainas sao pigmentos vacuolares e atoxicos that substituem as antocianinas e alguns fungos basidiomicetos.
Journal ArticleDOI
Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain.
Nichakarn Kwankaew,Hiroaki Okuda,Aye Aye-Mon,Tatsuya Ishikawa,Kiyomi Hori,Phattarapon Sonthi,Yu Kozakai,Noriyuki Ozaki +7 more
TL;DR: In this article, the effect of Betanin on microglial activation in the spinal cord of mice was investigated using primary microglia cultured cells, and the effect was shown to attenuate mechanical hypersensitivity in a dose-dependent manner without impairing motor coordination.
Journal ArticleDOI
Clarification of purple cactus pear juice using microfiltration membranes to obtain a solution of betalain pigments
Cristina Vergara,Beatriz Cancino-Madariaga,Andrés Ramírez-Salvo,Carmen Sáenz,Paz Robert,Mariane Lutz +5 more
TL;DR: In this paper, two 0.2 µm pore size microfiltration membranes (ceramic and polymeric) were tested and the best separation was obtained using the ceramic membrane.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Mitochondrial control of cell death
Guido Kroemer,John C. Reed +1 more
TL;DR: In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise, which has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
Journal ArticleDOI
Mitochondria as the central control point of apoptosis
TL;DR: The current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event are summarized.