Journal ArticleDOI
Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562.
Devalraju Sreekanth,M.K. Arunasree,Karnati R. Roy,T. Chandramohan Reddy,Gorla V. Reddy,Pallu Reddanna +5 more
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TLDR
It is demonstrated that betanin induces apoptosis in K562 cells through the intrinsic pathway and is mediated by the release of cytochrome c from mitochondria into the cytosol, and PARP cleavage.About:
This article is published in Phytomedicine.The article was published on 2007-11-05. It has received 211 citations till now. The article focuses on the topics: Betanin & Apoptosis.read more
Citations
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Production of betalains from callus and cell suspension cultures of Pereskia aculeata Miller, an unconventional leafy vegetable
Débora de Aguiar Lage,Matheus da Silva Tirado,Shade Ribeiro Vanicore,Kátia Costa de Carvalho Sabino,Norma Albarello +4 more
TL;DR: This study established an efficient protocol for betalain and biomass accumulation from callus and cell suspensions of P. aculeata Mill.
Journal ArticleDOI
Cacti for production of metabolites: current state and perspectives.
TL;DR: Analysis of the content of alkaloids, phenolic compounds, and terpenes present in cacti plants revealed that the level of some chemical constituents could give value added to these species from a nutritional, pharmacological, and biological point of view.
Journal ArticleDOI
Low-sugar content betaxanthins extracts from yellow pitaya (Stenocereus pruinosus)
Luisaldo Sandate-Flores,José Rodríguez-Rodríguez,Gonzalo Velazquez,Karla Mayolo-Deloisa,Marco Rito-Palomares,J. Antonio Torres,Roberto Parra-Saldívar +6 more
TL;DR: In this article, low-sugar betaxanthin preparations were obtained from a crude yellow pitaya Stenocereus pruinosus extract using aqueous two-phase systems (ATPS).
Journal ArticleDOI
Purification and neuroprotective effects of polysaccharides from Opuntia Milpa Alta in cultured cortical neurons.
TL;DR: Polysaccharides from Opuntia Milpa Alta might prevent intracellular calcium overload and decreased glutamate excitotoxicity, both of which can cause neuronal injury and death in vitro models of cerebral ischemic injury.
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Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression.
Deborah de Almeida Bauer Guimarães,Danielle dos Santos Bonfim de Castro,Felipe Leite de Oliveira,Eduardo de Matos Nogueira,Marco Antonio Mota da Silva,Anderson Junger Teodoro +5 more
TL;DR: Pitaya may have a protective effect against breast cancer, according to the antioxidant potential and influence of pitaya extract on cell viability, colony formation, cell cycle, apoptosis, and expression of BRCA1, BRCa2, PRAB, and Erα in breast cancer cell lines.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Mitochondrial control of cell death
Guido Kroemer,John C. Reed +1 more
TL;DR: In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise, which has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
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Mitochondria as the central control point of apoptosis
TL;DR: The current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event are summarized.