Journal ArticleDOI
Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla).
Jun Ma,Xiao-Dong Luo,Petr Protiva,Hui Yang,Cuiying Ma,Margaret J. Basile,I. Bernard Weinstein,Edward J. Kennelly +7 more
TLDR
Activity-guided fractionation of a methanol extract from the fruit of Manilkara zapota cv resulted in the isolation of two new antioxidants, methyl 4-O-galloylchlorogenate and 4- O-gallOYlchlorogenic acid, along with eight known polyphenolic antioxidants, namely, methyl chlorogenate, dihydromyricetin, quercitrin, and gallic acid.Abstract:
Activity-guided fractionation of a methanol extract from the fruit of Manilkara zapota cv. Tikal resulted in the isolation of two new antioxidants, methyl 4-O-galloylchlorogenate (1) and 4-O-galloylchlorogenic acid (2), along with eight known polyphenolic antioxidants, namely, methyl chlorogenate (3), dihydromyricetin (4), quercitrin (5), myricitrin (6), (+)-catechin (7), (−)-epicatechin (8), (+)-gallocatechin (9), and gallic acid (10). Of the 10 polyphenols, 1 showed the highest antioxidant activity (IC50 = 12.9 μM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC50 values of 190 and 160 μM, respectively. Compound 2 showed high antioxidant activity (IC50 = 23.5 μM) in the DPPH free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC50 values of 154 and 134 μM, respectively.read more
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Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications
TL;DR: This review includes various in vitro, in vivo and in silico studies providing the mode of action, radical scavenging activity, ability to inhibit lipid peroxidation, maintenance of endogenous defense systems and metal ion chelation by this triphenolic molecule, along with a comprehensive overview of factors responsible for its high antioxidant activity.
Journal ArticleDOI
Total Antioxidant Activity and Fiber Content of Select Florida-Grown Tropical Fruits
Kanjana Mahattanatawee,John A. Manthey,Gary A. Luzio,Stephen T. Talcott,Kevin L. Goodner,Elizabeth A. Baldwin +5 more
TL;DR: The antioxidant activities evaluated by both ORAC and DPPH showed similar trends where red guava and carambola exhibited the highest and sapodilla and green papaya exhibited the lowest levels and many of the tropical fruits were shown to contain an abundance of hydrolyzable tannins, ellagic acid conjugates, and flavone glycosides.
Journal ArticleDOI
Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
TL;DR: Gallic acid protects the myocardium against isoproterenol-induced oxidative stress, and Histopathological findings of gallic acid pretreated myocardial infarcted heart confirmed the biochemical findings of this study.
Journal ArticleDOI
Gallic acid: Molecular rival of cancer
TL;DR: The data so far available, both from in vivo and in vitro studies, indicate that this dietary polyphenol could be a promising agent in the field of cancer chemoprevention.
Journal ArticleDOI
Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies.
Angel Josabad Alonso-Castro,María Luisa Villarreal,Luis A. Salazar-Olivo,Maricela Gómez-Sánchez,Fabiola Domínguez,Alejandro García-Carrancá +5 more
TL;DR: A review of Mexican medicinal flora in terms of ethnobotanical, pharmacology, and chemistry of natural products related to anticancer activity indicates that it is time to increase the number of experimental studies and to conduct clinical trials with those Mexican plants and its active compounds selected by in vitro and in vivo activities.
References
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Journal ArticleDOI
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Marianne J. Engelhart,Mirjam I. Geerlings,Annemieke Ruitenberg,John C. van Swieten,Albert Hofman,Jacqueline C.M. Witteman,Monique M.B. Breteler +6 more
TL;DR: High dietary intake of vitamin C and vitamin E may lower the risk of Alzheimer disease.
Journal ArticleDOI
An investigation of antioxidant capacity of fruits in Singapore markets
Lai Peng Leong,Guanghou Shui +1 more
TL;DR: In this paper, the contribution of l-ascorbic acid (AA) to the total antioxidant activity of fruits was investigated by using RP-HPLC, which measured the change of absorbance of the free radical solution at 414 nm in the test reaction mixture following addition of the fruit extract, as compared with AA.
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Oxidative damage and defense.
Robert A. Jacob,B J Burri +1 more
TL;DR: Overall, the present data suggest that protection against oxidative damage and related disease is best served by the variety of antioxidant substances found in fruit and vegetables.
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Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells
TL;DR: The results of further studies suggested that the inhibition of proliferation and suppression of the EGF signaling by EGCG might mainly mediate dose‐dependent blocking of ligand binding to its receptor, and subsequently through inhibition of EGF‐R kinase activity.