Journal ArticleDOI
Biologic function of the Fc fragments of E myeloma protein
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The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.About:
This article is published in Immunochemistry.The article was published on 1970-08-01. It has received 146 citations till now. The article focuses on the topics: Fragment crystallizable region & Papain.read more
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Journal ArticleDOI
Identification of IgE.
TL;DR: Identification of IgE facilitated the analysis of immunologic mechanisms of reaginic hypersensitivity and revealed that IgE specifically bound to basophilic granulocytes and mast cells through the Fc portion of the molecules and that cross-linking of the cell-bound IgE antibody molecules by allergen induced the release of bioactive mediators, such as histamine and leukotrienes, which initiate allergic reactions.
Journal ArticleDOI
Mechanism of activation of human basophils by Staphylococcus aureus Cowan 1.
Gianni Marone,M. Tamburini,Maria Grazia Giudizi,Roberta Biagiotti,Fabio Almerigogna,Sergio Romagnani +5 more
TL;DR: Hyperiodination of Staph A, which destroys over 90% of the original Fc reactivity without altering the Fab-binding site, did not alter the ability of the protein to induce histamine release.
ITS DEPENDENCE UPON IgE ANTIBODIES
TL;DR: It is shown that the intradermal injection of a number of different allergens can produce a prolonged inflammatory reaction after the immediate wheal and flare in most sensitive subjects.
Journal ArticleDOI
A Conformational Rearrangement upon Binding of IgE to Its High Affinity Receptor
TL;DR: Binding experiments show that when IgE interacts with α-t there is a 15-26% decrease of the negative ellipticity at 217 nm, which indicates that upon binding, a major conformational rearrangement must occur on IgE.
Book ChapterDOI
Human Lymphocyte-Dependent Cytotoxic Antibody and Mechanisms of Target Cell Destruction in Vitro
TL;DR: In this article, the authors present recent studies on manifestations of delayed cellular hypersensitivity in vitro and in vivo, at least two different migration-inhibiting activities originating from the interaction of hypersensitive lymphocytes with the specific antigen were produced.
References
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Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
Estimation of the molecular weights of proteins by Sephadex gel-filtration.
TL;DR: The results are similar to those of previous studies, where the objective was to establish a cause-and-effect relationship, rather than a straightforward relationship between the number of cells and the content of the molecule.
Related Papers (5)
Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.
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Anthony Kulczycki,Henry Metzger +1 more