Journal ArticleDOI
Biologic function of the Fc fragments of E myeloma protein
Reads0
Chats0
TLDR
The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.About:
This article is published in Immunochemistry.The article was published on 1970-08-01. It has received 146 citations till now. The article focuses on the topics: Fragment crystallizable region & Papain.read more
Citations
More filters
Book ChapterDOI
Molecular basis of Fc receptor function.
Mark D. Hulett,P. Mark Hogarth +1 more
TL;DR: The structural analysis of the functional basis of FcγR and FCɛR signaling is beginning to shed some light on the way these receptors trigger biological responses, and the molecular dissection of the pathways involved in signaling is also underway.
Journal ArticleDOI
The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
TL;DR: The results of the study suggest that IgE-allergen interaction on the surfaces of mast cells or on infiltrating basophils causes both immediate and late cutaneous responses.
Journal ArticleDOI
Molecular structure of human lymphocyte receptor for immunoglobulin E
Hitoshi Kikutani,S. Inui,Ryoichi Sato,Barsumian Edward L,Hajime Owaki,Katsuhiko Yamasaki,Tsuneyasu Kaisho,Naoto Uchibayashi,Richard R. Hardy,Toshio Hirano,Susumu Tsunasawa,Fumio Sakiyama,Masaki Suemura,Tadamitsu Kishimoto +13 more
TL;DR: A cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R) is isolated and shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc ePSilon R in endocytosis.
Journal ArticleDOI
Two species of human Fcε receptor II (FcεRIICD23): Tissue-specific and IL-4-specific regulation of gene expression
Akira Yokota,Hitoshi Kikutani,Tetsuji Tanaka,Ryoichi Sato,Barsumian Edward L,Masaki Suemura,Tadamitsu Kishimoto +6 more
TL;DR: Sequence analysis of the cloned cDNAs revealed that these Fc epsilon RII species appear to be generated utilizing different transcriptional initiation sites and alternative RNA splicing, which may explain the difference in Fc wtihin B cells and the effector phase of IgE-mediated immunity.
Journal ArticleDOI
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS : II. Quantitative Aspects of the Binding Reaction
Anthony Kulczycki,Henry Metzger +1 more
TL;DR: The reaction mechanism appears to consist of a simple reversible binding reaction with k 1 = 9.6 x 104 M–1 sec–1 and k –1 ⩽ 1.8 kcal/mol, and the calculated KA is therefore ⩾ 6 x 109 M-1.
References
More filters
Journal Article
Induction of erythema-wheal reactions by soluble antigen-gammaE antibody complexes in humans.
TL;DR: It was found that γE-antibody complexes induced positive skin reactions, whereas neither γG- nor γA-antibia complexes did, and analysis by sucrose density gradient ultracentrifugation strongly suggests the requirement of two or more antibody molecules for the formation of an active complex.
Journal Article
Biologic Activities of Aggregated Immunoglobulin E
TL;DR: Evidence was presented that combination of the aggregated γE with target cells, to which reaginic antibodies attach upon sensitization, is essential for induction of the skin reactions in the primates.
Journal Article
Skin-sensitizing activity related to gamma- polypeptide chain characteristics of human IgG.
TL;DR: Human G-myeloma proteins differ in their ability to sensitize guinea pig skin for reverse passive cutaneous anaphylaxis, and skin-sensitizing activity correlates with γ-chain antigenic characteristics of these molecules.
Journal Article
Structure of human immunoglobulin M. 3. Pepsin fragmentation of IgM.
TL;DR: Time study of the digestion showed that pepsin first cleaved off the Fc portion of the IgM and yielded the 5.6 S dimeric fragment, F(ab′)2, which was degraded to the 3.3 S monomer, Fab pep, and further to the 2.4 S fragment, Fab piece.
Journal Article
Heterogeneity in antibodies specific for aggregated human gammaG-globulin.
TL;DR: In this article, the authors compared the specificity of antibodies produced by aggregated human γG-globulin under autologous, isologous and heterologous conditions, and found that the antigenic determinants eliciting antibody production were located in the F c region of the aggregated antigen.
Related Papers (5)
Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS : II. Quantitative Aspects of the Binding Reaction
Anthony Kulczycki,Henry Metzger +1 more