Journal ArticleDOI
Biologic function of the Fc fragments of E myeloma protein
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The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.About:
This article is published in Immunochemistry.The article was published on 1970-08-01. It has received 146 citations till now. The article focuses on the topics: Fragment crystallizable region & Papain.read more
Citations
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Book ChapterDOI
Molecular basis of Fc receptor function.
Mark D. Hulett,P. Mark Hogarth +1 more
TL;DR: The structural analysis of the functional basis of FcγR and FCɛR signaling is beginning to shed some light on the way these receptors trigger biological responses, and the molecular dissection of the pathways involved in signaling is also underway.
Journal ArticleDOI
The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
TL;DR: The results of the study suggest that IgE-allergen interaction on the surfaces of mast cells or on infiltrating basophils causes both immediate and late cutaneous responses.
Journal ArticleDOI
Molecular structure of human lymphocyte receptor for immunoglobulin E
Hitoshi Kikutani,S. Inui,Ryoichi Sato,Barsumian Edward L,Hajime Owaki,Katsuhiko Yamasaki,Tsuneyasu Kaisho,Naoto Uchibayashi,Richard R. Hardy,Toshio Hirano,Susumu Tsunasawa,Fumio Sakiyama,Masaki Suemura,Tadamitsu Kishimoto +13 more
TL;DR: A cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R) is isolated and shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc ePSilon R in endocytosis.
Journal ArticleDOI
Two species of human Fcε receptor II (FcεRIICD23): Tissue-specific and IL-4-specific regulation of gene expression
Akira Yokota,Hitoshi Kikutani,Tetsuji Tanaka,Ryoichi Sato,Barsumian Edward L,Masaki Suemura,Tadamitsu Kishimoto +6 more
TL;DR: Sequence analysis of the cloned cDNAs revealed that these Fc epsilon RII species appear to be generated utilizing different transcriptional initiation sites and alternative RNA splicing, which may explain the difference in Fc wtihin B cells and the effector phase of IgE-mediated immunity.
Journal ArticleDOI
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS : II. Quantitative Aspects of the Binding Reaction
Anthony Kulczycki,Henry Metzger +1 more
TL;DR: The reaction mechanism appears to consist of a simple reversible binding reaction with k 1 = 9.6 x 104 M–1 sec–1 and k –1 ⩽ 1.8 kcal/mol, and the calculated KA is therefore ⩾ 6 x 109 M-1.
References
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Journal Article
Biologic activity of aggregated gamma-globulin. II. A study of various methods for aggregation and species differences.
TL;DR: The mechanism for the induction of the biologic activities by the formation of aggregated γ-globulin and of antigen-antibody complexes was discussed.
Journal ArticleDOI
Stepwise cleavage of rabbit immunoglobin G by papain and isolation of four types of biologically active Fc fragments
TL;DR: Four types of Fc fragments of different sizes were isolated by papain treatment of rabbit immunoglobulin G under various conditions and by subsequent chromatographic procedures, finding that the antigenic structure was intact and the complement-binding activities were retained.
Journal ArticleDOI
Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (srs-a) in the guinea pig and rat*
TL;DR: Two different mechanisms for the production of PCA lesions in the rat were considered, one of these involves the antigen-induced release of histamine and serotonin from mast cells sensitized by homocytotropic antibody and the other involves the local combination of antigen with "hyperimmune" heterologous or homologous antisera.
Journal Article
Immunochemical properties of human gamma-A isohemagglutinin. I. Comparisons with gamma-G and gamma-M-globulin antibodies.
TL;DR: The IgA isoagglutinin did not sensitize guinea pig skin for passive cutaneous anaphylaxis, and the antibody activity of the monomer form IgA antibody was lower than that of the polymer form antibody, but higher than thatof IgG antibody.
Journal Article
Studies on the immunologic mechanism of anaphylaxis. II. Sensitizing and combining capacity in vivo of fractions separated from papain digests of antihapten antibody.
Zoltan Ovary,Fred Karush +1 more
TL;DR: It was concluded that the failure of ADDS and ADS-I to produce PCA or RPCA reactions is due to their inability to be “fixed” to the guinea pig tissues and that this “fixation” site is present on ADDP.
Related Papers (5)
Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS : II. Quantitative Aspects of the Binding Reaction
Anthony Kulczycki,Henry Metzger +1 more