Journal ArticleDOI
Biologic function of the Fc fragments of E myeloma protein
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The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.About:
This article is published in Immunochemistry.The article was published on 1970-08-01. It has received 146 citations till now. The article focuses on the topics: Fragment crystallizable region & Papain.read more
Citations
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La sensibilisationpassive in vitro du basophile humain: un modèle expérimental pour l'étude de la fixation cellulaire des IgE in vivo
TL;DR: In this article, les auteurs decrivent les modalites experimentales de la sensibilisation passive in vitro du basophile humain par des IgE seriques ou de myelome.
Journal ArticleDOI
Relationship between IgE and platelet function
Shosaku Nomura,Hirokazu Nagata,Mutsumasa Yanabu,Masahiko Suzuki,Tetsuji Soga,Toshishige Ohga,Koji Kondo,Naoaki Sone,Chikaho Kitada,Hiroyuki Kitajima,Terutoshi Kokawa,Kojiro Yasunaga +11 more
TL;DR: The results suggest that IgE binds to not the Fc-receptor but the GPIIb/IIIa-related receptor on the platelet surface, whereas the increased IgE dose does not appear to effect on the Platelet function.
Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE Antibody
TL;DR: In this article, the authors showed that the epitopes in the Fc region of IgE that bind to both FceRII and FceRI may overlap, and that the development of an IgE 24antagonist that blocks IgE binding to both receptors may have a significant effect on the immunoregulation of allergic disease.
Journal ArticleDOI
Leucocyte histamine release studies and skin tests with aggregated gamma-globulin in hypogammaglobulinaemia.
M. J. Schumacher,E. F. Ellis +1 more
TL;DR: The results suggest that systemic reactions to aggregated γ-globulin in patients with immunological deficiency are unlikely to be mediated by intravascular histamine release.
References
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Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
Estimation of the molecular weights of proteins by Sephadex gel-filtration.
TL;DR: The results are similar to those of previous studies, where the objective was to establish a cause-and-effect relationship, rather than a straightforward relationship between the number of cells and the content of the molecule.
Related Papers (5)
Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS : II. Quantitative Aspects of the Binding Reaction
Anthony Kulczycki,Henry Metzger +1 more