Journal ArticleDOI
Biologic function of the Fc fragments of E myeloma protein
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The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.About:
This article is published in Immunochemistry.The article was published on 1970-08-01. It has received 146 citations till now. The article focuses on the topics: Fragment crystallizable region & Papain.read more
Citations
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Standardization of radioimmunoassay: differences in reactivity of rat IgEs with antibodies to a monoclonal IgE.
TL;DR: Results suggest the existence of subclasses of IgE, especially in competitive inhibition radioimmunoassays designed for the quantitation of total IgE in rat sera, using immunospecifically purified antibodies to the class-specific IgE determinants.
Journal ArticleDOI
The structural basis of human IgE-Fc receptor interactions
Ian Sayers,Birgit A. Helm +1 more
TL;DR: How structure-function studies on the interaction of hIgE with its receptors can assist the development of more effective and safer anti-allergic drugs is evaluated.
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Immunopharmacological aspects of bronchial asthma
TL;DR: It is now apparent that in order to account for the pathological changes observed in bronchial asthma, the purported chemical mediators must be capable of more than simply contracting bronchia smooth muscle.
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Inhibitory Effect on β -Hexosaminidase Release from RBL-2H3 Cells of Extracts and Some Pure Constituents of Benchalokawichian, a Thai Herbal Remedy, Used for Allergic Disorders
TL;DR: This study provides some support for the use of BCW in reducing itching and treatment of other skin allergic disorders and further phytochemical and safety studies of pure compounds are required before development of these as antiallergy commercial remedies.
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Studies of the Ige Binding-sites To Rat Mast-cell Receptor With Proteolytic Fragments and With a Monoclonal-antibody Directed Against Epsilon Heavy-chain - Evidence That the Combining Sites Are Located in the -episilon-3 Domain
TL;DR: Results indicate that the binding sites of IgE to rat mast cell receptor are located within the C, 3 domain, which will be useful to evaluate its participation in the affinity of Ig E to receptors of other cells such as lymphocytes or macrophages.
References
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Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
Estimation of the molecular weights of proteins by Sephadex gel-filtration.
TL;DR: The results are similar to those of previous studies, where the objective was to establish a cause-and-effect relationship, rather than a straightforward relationship between the number of cells and the content of the molecule.
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