Journal ArticleDOI
Biomarkers of aging and disease: introduction and definitions.
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TLDR
The biomarkers discussed in this issue are generally easier to understand, can be related to relevant functions, and often are the product of concentrated research interest, and thus are often of very immediate interest.About:
This article is published in Experimental Gerontology.The article was published on 2010-01-01. It has received 163 citations till now. The article focuses on the topics: Biomarkers of aging.read more
Citations
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Journal ArticleDOI
Quantification of biological aging in young adults.
Daniel W. Belsky,Avshalom Caspi,Renate Houts,Harvey J. Cohen,David L. Corcoran,Andrea Danese,HonaLee Harrington,Salomon Israel,Morgan E. Levine,Jonathan D. Schaefer,Karen Sugden,Ben Williams,Anatoli I. Yashin,Richie Poulton,Terrie E. Moffitt +14 more
TL;DR: It is indicated that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies.
Journal ArticleDOI
Brain age predicts mortality
James H. Cole,Stuart J. Ritchie,Mark E. Bastin,M C Valdés Hernández,S. Muñoz Maniega,Natalie A. Royle,Janie Corley,Alison Pattie,Sarah E. Harris,Qian Zhang,Naomi R. Wray,Paul Redmond,Riccardo E. Marioni,Riccardo E. Marioni,John M. Starr,Simon R. Cox,Joanna M. Wardlaw,David J. Sharp,Ian J. Deary +18 more
TL;DR: This study introduces a clinically-relevant neuroimaging ageing biomarker ‘brain-predicted age’ and demonstrates that combining distinct measurements of biological ageing further helps to determine risk of age-related deterioration and death.
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Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Jason L. Sanders,Anne B. Newman +1 more
TL;DR: It is demonstrated that shorter LTL is associated with older age, male gender, Caucasian race, and possibly atherosclerosis; associations with other markers of health are equivocal.
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Identifying and validating biomarkers for Alzheimer's disease
TL;DR: It seems likely that only a combined analysis of several biomarkers will define a patient-specific signature to diagnose AD in the future.
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Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?
TL;DR: The Klemera and Doubal method was the most reliable predictor of mortality and performed significantly better than chronological age, when included with chronological age in a model, which caused chronological age to no longer be significantly associated with mortality.
References
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Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
Journal ArticleDOI
Genes that regulate both development and longevity in Caenorhabditis elegans.
TL;DR: Genetic analysis of mutations that alter dauer larva formation (daf mutations) is presented along with an updated genetic pathway for dauer vs. nondauer development, which shows the largest genetic extension of life span yet observed in a metazoan.
Journal ArticleDOI
Biomarkers of aging: From primitive organisms to humans
Robert N. Butler,Richard L. Sprott,Huber R. Warner,Jeffrey Bland,Richie Feuers,Michael J. Forster,Howard Fillit,S. Mitchell Harman,Michael J. Hewitt,Mark Hyman,Kathleen Johnson,Evan W. Kligman,Gerald E. McClearn,James F. Nelson,Arlan Richardson,William E. Sonntag,Richard Weindruch,Norman S. Wolf +17 more
TL;DR: Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large.
Book
Handbook of models for human aging
TL;DR: In this paper, the authors compare models of aging and age-related diseases using animal models and comparative models of different types of aging models, such as aging and aging-related disorders.