Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research
TLDR
It is suggested that the development of biological biomarkers, measured in both blood and urine, are essential for making accurate estimates of polyphenol intake, but the relationship between dietary intakes and nutritional biomarkers are often highly complex.Abstract:
In order to establish firm evidence for the health effects of dietary polyphenol consumption, it is essential to have quantitative information regarding their dietary intake. The usefulness of the current methods, which rely mainly on the assessment of polyphenol intake using food records and food composition tables, is limited as they fail to assess total intake accurately. This review highlights the problems associated with such methods with regard to polyphenol-intake predictions. We suggest that the development of biological biomarkers, measured in both blood and urine, are essential for making accurate estimates of polyphenol intake. However, the relationship between dietary intakes and nutritional biomarkers are often highly complex. This review identifies the criteria that must be considered in the development of such biomarkers. In addition, we provide an assessment of the limited number of potential biomarkers of polyphenol intake currently available.read more
Citations
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Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
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Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases
Daniele Del Rio,Ana Rodriguez-Mateos,Jeremy P. E. Spencer,Massimiliano Tognolini,Gina Borges,Alan Crozier +5 more
TL;DR: It is concluded that better performed in vivo intervention and in vitro mechanistic studies are needed to fully understand how (poly)phenol molecules interact with human physiological and pathological processes.
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Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
TL;DR: This review aims at exploring the properties of polyphenols in anti-inflammation and oxidation and the mechanisms ofpolyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of poly phenols in inflammation-mediated chronic disorders.
Journal ArticleDOI
Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
David Vauzour,Ana Rodriguez-Mateos,Giulia Corona,Maria Jose Oruna-Concha,Jeremy P. E. Spencer +4 more
TL;DR: The role that polyphenols play in the prevention of cancer, cardiovascular disease and neurodegeneration is provided and epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions are presented.
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Resources and biological activities of natural polyphenols.
TL;DR: This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity.
References
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Polyphenols: food sources and bioavailability
TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Journal ArticleDOI
Dietary Intake and Bioavailability of Polyphenols
TL;DR: Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides.
Journal ArticleDOI
Vegetables, Fruit, and Cancer Prevention: A Review
TL;DR: The evidence for a protective effect of greater vegetable and fruit consumption is consistent for cancers of the stomach, esophagus, lung, oral cavity and pharynx, endometrium, pancreas, and colon, and the types of vegetables or fruit that most often appear to be protective against cancer are raw vegetables.
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Optimal diets for prevention of coronary heart disease.
Frank B. Hu,Walter C. Willett +1 more
TL;DR: Substantial evidence indicates that diets using nonhydrogenated unsaturated fats as the predominant form of dietary fat, whole grains as the main form of carbohydrates, an abundance of fruits and vegetables, and adequate omega-3 fatty acids can offer significant protection against CHD.
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The flavonoids. A class of semi-essential food components: their role in human nutrition.
TL;DR: A review of the chemistry, the fate of food flavonoids, and their nutritional effects can be found in this paper, where the authors discuss the antibiotic and/or bacteriostatic effects of foods rich in these compounds.