Journal ArticleDOI
Blood protein profiles of infants born before 28 weeks differ by pregnancy complication
Thomas F. McElrath,Raina N. Fichorova,Elizabeth N. Allred,Jonathan L. Hecht,Mahmoud A. Ismail,Huaiping Yuan,Alan Leviton +6 more
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TLDR
The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2011-05-01. It has received 61 citations till now. The article focuses on the topics: Pregnancy disorder & Preeclampsia.read more
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Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
Esther F. Davis,Laura Newton,Laura Newton,Adam J. Lewandowski,Merzaka Lazdam,Brenda Kelly,Theodosios Kyriakou,Paul Leeson +7 more
TL;DR: The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu.
Journal ArticleDOI
Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants
T. Michael O’Shea,Bhavesh Shah,Elizabeth N. Allred,Raina N. Fichorova,Karl C.K. Kuban,Olaf Dammann,Alan Leviton +6 more
TL;DR: It is concluded that elevated blood concentrations of inflammation-related proteins provide information about the risk of impaired cognitive function at age 2 years that supplements information provided by inflammation-associated illnesses.
Journal ArticleDOI
Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation
Alan Leviton,Raina N. Fichorova,T. Michael O’Shea,Karl C.K. Kuban,Karl C.K. Kuban,Nigel Paneth,Olaf Dammann,Elizabeth N. Allred,Elizabeth N. Allred +8 more
TL;DR: SGA appears to place very preterm newborns at an increased risk of a very low MDI, and systemic inflammation adds considerably to the increased risk.
Journal ArticleDOI
Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants
T. Michael O'Shea,Robert M. Joseph,Karl C.K. Kuban,Elizabeth N. Allred,Janice Ware,Taryn Coster,Raina N. Fichorova,Olaf Dammann,Olaf Dammann,Alan Leviton +9 more
TL;DR: Among children born extremely prematurely, recurrent, or persistent elevations of inflammation-related proteins in blood during in the first two postnatal weeks are associated with an attention problem at age 2 y.
Journal ArticleDOI
The role of systemic inflammation linking maternal BMI to neurodevelopment in children
Jelske W. van der Burg,Jelske W. van der Burg,Sarbattama Sen,Sarbattama Sen,Virginia R. Chomitz,Jaap Seidell,Alan Leviton,Olaf Dammann,Olaf Dammann,Olaf Dammann +9 more
TL;DR: This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children.
References
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Journal ArticleDOI
Epidemiology and causes of preterm birth
TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
Journal ArticleDOI
No adjustments are needed for multiple comparisons.
TL;DR: A policy of not making adjustments for multiple comparisons is preferable because it will lead to fewer errors of interpretation when the data under evaluation are not random numbers but actual observations on nature.
Journal ArticleDOI
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Sharon Maynard,Jiang Yong Min,Jaime R. Merchan,Kee-Hak Lim,Jianyi Li,Susanta Mondal,Towia A. Libermann,James P. Morgan,Frank W. Sellke,Isaac E. Stillman,Franklin H. Epstein,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: It is confirmed that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt 1 that fall after delivery, and observations suggest that excess circulating sFelt1 contributes to the pathogenesis of preeClampsia.
Journal ArticleDOI
Circulating Angiogenic Factors and the Risk of Preeclampsia
Richard J. Levine,Sharon Maynard,Cong Qian,Kee-Hak Lim,Lucinda England,Kai F. Yu,Enrique F. Schisterman,Ravi Thadhani,Benjamin P. Sachs,Franklin H. Epstein,Bahaeddine M Sibai,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: Alterations in the levels of sFlt-1 and free PlGF were greater in women with an earlier onset of preeclampsia and in women in whom preeClampsia was associated with a small-for-gestational-age infant.
Journal ArticleDOI
Intrauterine infection and preterm delivery.
TL;DR: Preterm delivery is the chief problem in obstetrics today, accounting for 70 percent of perinatal mortality and nearly half of long-term neurologic morbidity, and the remainder follow the spontaneous onset of labor or rupture.
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