Brain-Derived Neurotrophic Factor and Its Serum Levels in Schizophrenic Patients
Yvetta A Koeva,Stefan T. Sivkov,Valentin H. Akabaliev,Roumiana Y. Ivanova,Tania I. Deneva,Lilia S. Grozlekova,Vessela Georgieva +6 more
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TLDR
The BDNF reduction in serum indicates a potential deficit in neurotrophic factor release in patients with schizophrenia and support the concept that BDNF might be associated with schizophrenia.Abstract:
Introduction Neurotrophins have an important role in regulating the development and maintenance of the peripheral and central nervous systems' function. Thus, the neurotrophin hypothesis of schizophrenia has postulated that the changes in the brain of schizophrenic patients are the result of disturbances of developing processes involving these molecules. Aim We analyse in the present study the changes in the serum levels of brain-derived neurotrophic factor (BDNF) in schizophrenic patients as possible epiphenomena of underlying alterations of the neurotrophic factor in central nervous system, reflecting its role in the pathophysiology of schizophrenia. Patients and methods Twenty-one schizophrenic patients satisfying the DSM-IV criteria for diagnosis of schizophrenia were enrolled in the study. The control group consisted of 28 age-matched mentally healthy subjects. Serum BDNF levels were determined in patients and normal controls using ELISA (Chemicon International, USA & Canada). The data were analyzed statistically with Student's t- test in SPSS 9.0. Results The serum BDNF levels were lower in the schizophrenic patients than in the control subjects, reaching statistically significant difference (t = 2.72, p = 0.009). Female patients had lower serum BDNF levels than the male patients but the difference fell short of statistical significance (t = 0.1, p = 0.9). Conclusions The BDNF reduction in serum indicates a potential deficit in neurotrophic factor release in patients with schizophrenia and support the concept that BDNF might be associated with schizophrenia.read more
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Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia.
TL;DR: Lower BDNF and higher NT-3 serum levels in depressed patients with schizophrenia are found and these levels are similar to those found in controls.
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Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness
TL;DR: It is suggested that using nanoparticulate drug-delivery systems may substantially contribute to the development of clinically viable techniques for BDNF delivery into the cochlea or posterior eye segment, which, ultimately, can lead to a long-term or permanent rescue of auditory and optic neurons from degeneration.
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Neuroprotective and restorative effects of the brain-derived neurotrophic factor in retinal diseases.
TL;DR: Although much of the evidence have validated the protective properties of BDNF against various retinal cell diseases, bringing such insights into clinical context would depend on further well-designed research.
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Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder.
TL;DR: The notion of scaffolding as the outcome of physical exercise implies the “buttressing” of regional network circuits, neurocognitive domains, anti-inflammatory defenses, maintenance of telomeric integrity, and neuro-reparative and regenerative processes.
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Effect of lurasidone vs olanzapine on neurotrophic biomarkers in unmedicated schizophrenia: A randomized controlled trial.
Monalisa Jena,Rajeev Ranjan,Biswa Ranjan Mishra,Archana Mishra,Santanu Nath,Pallabi Sahu,Bikash Ranjan Meher,Anand Srinivasan,Rituparna Maiti +8 more
TL;DR: It is suggested that increase in serum BDNF with olanzapine monotherapy is significantly higher than that with lurasidone but there is no significant difference in change in serum NGF and NT3.
References
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Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients.
M. Takahashi,Osamu Shirakawa,Kazuhiko Toyooka,Noboru Kitamura,Takeshi Hashimoto,Kiyoshi Maeda,S Koizumi,Koichi Wakabayashi,Hitoshi Takahashi,Toshiyuki Someya,Hiroyuki Nawa +10 more
TL;DR: Levels of neurotrophins and their receptors in the postmortem brains of schizophrenic patients and control subjects in relation to molecular impairments in schizophrenia suggest that neurotrophic abnormality is associated with the corticolimbic structures of schizophrenia and might provide the molecular substrate for pathological manifestations of the illness.
Journal ArticleDOI
Neurotrophin trafficking by anterograde transport
TL;DR: The ever-unfolding biology of NGF is consistent with a target-derived retrograde mode of action in peripheral and central neurons, but another member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), is present within nerve terminals in certain regions of the brain and PNS that do not contain the corresponding mRNA.
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Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.
TL;DR: The findings show abnormal BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders, indicating that fundamental properties of hippocampal signalling transmission, plasticity and circuitry may be affected in individuals with these major mental illnesses.
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Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients.
Kazuhiko Toyooka,Koue Asama,Yuichiro Watanabe,Tatsuyuki Muratake,Makoto Takahashi,Toshiyuki Someya,Hiroyuki Nawa +6 more
TL;DR: The BDNF reduction in serum but not in whole blood suggests a potential deficit in neurotrophic factor release in patients with schizophrenia, and this study assessed peripheral BDNF levels in whole and serum of schizophrenic patients and healthy volunteers.
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Coexpression of neurotrophins and their receptors in neurons of the central nervous system
TL;DR: The results show that individual neurons of the central nervous system can coexpress neurotrophins and their receptors and produce two neurotrophic factors, which could support neuronal survival after brain insults, not only via retrograde transport but also through autocrine mechanisms.