British Society for Sexual Medicine Guidelines on Adult Testosterone Deficiency, With Statements for UK Practice.
Geoffrey Hackett,Mike Kirby,David Edwards,Thomas Hugh Jones,Kevan Wylie,Nick Ossei-Gerning,Janine David,Asif Muneer +7 more
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TLDR
Improving the diagnosis and management of TD in adult men should provide somatic, sexual, and psychological benefits and subsequent improvements in quality of life.About:
This article is published in The Journal of Sexual Medicine.The article was published on 2017-12-01 and is currently open access. It has received 94 citations till now. The article focuses on the topics: Evidence-based medicine & Sexual medicine.read more
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Journal ArticleDOI
Paediatric and adult-onset male hypogonadism
Andrea Salonia,Giulia Rastrelli,Geoffrey Hackett,Stephanie B. Seminara,Ilpo Huhtaniemi,Ilpo Huhtaniemi,Rodolfo Rey,Wayne J.G. Hellstrom,Mark R. Palmert,Giovanni Corona,Gert R. Dohle,Mohit Khera,Yee-Ming Chan,Yee-Ming Chan,Mario Maggi +14 more
TL;DR: This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypog onadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.
Journal ArticleDOI
British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men-2017
Geoffrey Hackett,Mike Kirby,Kevan Wylie,Adrian Heald,Nick Ossei-Gerning,David Edwards,Asif Muneer +6 more
TL;DR: There is now overwhelming evidence that erectile dysfunction is strongly associated with cardiovascular disease, such that newly presenting patients should be thoroughly evaluated for cardiovascular and endocrine risk factors, which should be managed accordingly.
Journal ArticleDOI
Male Obesity-related Secondary Hypogonadism - Pathophysiology, Clinical Implications and Management.
TL;DR: If lifestyle-measures fail to relieve symptoms and to normalise testosterone levels, in appropriately selected men, testosterone replacement therapy could be started and aromatase inhibitors and selective oestrogen receptor modulators are not recommended due to lack of consistent clinical trial-based evidence.
Journal ArticleDOI
Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality.
TL;DR: Long-term testosterone therapy with testosterone undecanoate for up to 12 years alleviates ED, improves cardiometabolic risk factors, and reduces prostate cancer.
Journal ArticleDOI
Testosterone replacement therapy.
TL;DR: The aim of testosterone replacement therapy (TRT) is to improve symptoms and signs of testosterone deficiency including decreased libido, erectile dysfunction, depressed mood, anaemia, loss of muscle and bone mass, by increasing serum testosterone levels to physiologic range.
References
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Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
TL;DR: Gutman et al. as mentioned in this paper showed that the acid phosphatase of serum is reduced in metastatic carcinoma of the prostate by decreasing the activity of androgens through castration or estrogenic injections and that this enzyme is increased by injecting androgens.
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A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
TL;DR: The FT value, obtained by calculation from T and SHBG as determined by immunoassay, appears to be a rapid, simple, and reliable index of bioavailable T, comparable to AFTC and suitable for clinical routine, except in pregnancy.
Journal Article
Studies on Prostatic Cancer. I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate
TL;DR: It is demonstrated that a marked rise in acid phosphatase in serum is associated with the appearance or spread of roentgenologically demonstrable skeletal metastases and implies dissemination of the primary tumor and thus is of unfavorable prognostic significance.
Journal ArticleDOI
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
Shalender Bhasin,Glenn R. Cunningham,Frances J. Hayes,Alvin M. Matsumoto,Peter J. Snyder,Ronald S. Swerdloff,Victor M. Montori +6 more
TL;DR: The guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006 were updated by the Task Force of the Clinical Guidelines Subcommittee of The Endocrine Society.
Journal ArticleDOI
Adverse Events Associated with Testosterone Administration
Shehzad Basaria,Andrea D. Coviello,Thomas G. Travison,Thomas W. Storer,Wildon Farwell,Wildon Farwell,Alan M. Jette,Richard Eder,Sharon L. Tennstedt,Jagadish Ulloor,Anqi Zhang,Karen Choong,Kishore M. Lakshman,Norman A. Mazer,Renee Miciek,Joanne B. Krasnoff,Ayan Elmi,Philip E. Knapp,Brad Brooks,Erica R. Appleman,Sheetal Aggarwal,Geeta Bhasin,Leif Hede-Brierley,Ashmeet Bhatia,Lauren Collins,Nathan K. LeBrasseur,Louis D. Fiore,Shalender Bhasin +27 more
TL;DR: In this population of older men with limitations in mobility and a high prevalence of chronic disease, the application of a testosterone gel was associated with an increased risk of cardiovascular adverse events.
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Identification of late-onset hypogonadism in middle-aged and elderly men.
Frederick C. W. Wu,Abdelouahid Tajar,Jennifer M. Beynon,Stephen R Pye,Alan J. Silman,Joseph D. Finn,Terence W O'Neill,Gyorgy Bartfai,Felipe F. Casanueva,Gianni Forti,Aleksander Giwercman,Thang S. Han,Krzysztof Kula,Michael E. J. Lean,Neil Pendleton,Margus Punab,Steven Boonen,Dirk Vanderschueren,Fernand Labrie,Ilpo Huhtaniemi +19 more
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Adverse Events Associated with Testosterone Administration
Shehzad Basaria,Andrea D. Coviello,Thomas G. Travison,Thomas W. Storer,Wildon Farwell,Wildon Farwell,Alan M. Jette,Richard Eder,Sharon L. Tennstedt,Jagadish Ulloor,Anqi Zhang,Karen Choong,Kishore M. Lakshman,Norman A. Mazer,Renee Miciek,Joanne B. Krasnoff,Ayan Elmi,Philip E. Knapp,Brad Brooks,Erica R. Appleman,Sheetal Aggarwal,Geeta Bhasin,Leif Hede-Brierley,Ashmeet Bhatia,Lauren Collins,Nathan K. LeBrasseur,Louis D. Fiore,Shalender Bhasin +27 more