Paediatric and adult-onset male hypogonadism
Andrea Salonia,Giulia Rastrelli,Geoffrey Hackett,Stephanie B. Seminara,Ilpo Huhtaniemi,Ilpo Huhtaniemi,Rodolfo Rey,Wayne J.G. Hellstrom,Mark R. Palmert,Giovanni Corona,Gert R. Dohle,Mohit Khera,Yee-Ming Chan,Yee-Ming Chan,Mario Maggi +14 more
- Vol. 5, Iss: 1, pp 38
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TLDR
This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypog onadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.Abstract:
The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development. Male hypogonadism is a disorder associated with low testosterone levels and impaired spermatogenesis. The condition can arise from inherent defects in the testes or abnormalities in the regulation of testosterone secretion at the hypothalamic or pituitary level. This Primer summarizes the conditions that can lead to hypogonadism in boys and men.read more
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Journal ArticleDOI
European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Andrea Salonia,C Bettocchi,Luca Boeri,Paolo Capogrosso,Joana Carvalho,Nusret Can Cilesiz,Andrea Cocci,Giovanni Corona,Kostantinos Dimitropoulos,Murat Gul,Georgios Hatzichristodoulou,T Hugh Jones,Ates Kadioglu,Juan Ignatio Martínez Salamanca,Uros Milenkovic,Vaibhav Modgil,Giorgio Ivan Russo,Ege Can Serefoglu,Tharu Tharakan,Paolo Verze,Suks Minhas +20 more
TL;DR: The European Association of Urology (EAU) guidelines on male sexual health were updated in March 2019, with a last comprehensive update in January 2019 as mentioned in this paper, with a systematic review of the evidence or a consensus opinion from the expert panel.
Journal ArticleDOI
European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility
Suks Minhas,C Bettocchi,Luca Boeri,Paolo Capogrosso,Joana Carvalho,Nusret Can Cilesiz,Andrea Cocci,Giovanni Corona,Konstantinos Dimitropoulos,Konstantinos Dimitropoulos,Murat Gul,Georgios Hatzichristodoulou,Thomas Hugh Jones,Ates Kadioglu,Juan Ignatio Martínez Salamanca,Uros Milenkovic,Vaibhav Modgil,Giorgio Ivan Russo,Ege Can Serefoglu,Tharu Tharakan,Paolo Verze,Andrea Salonia +21 more
TL;DR: The European Association of Urology (EAU) has updated its guidelines on sexual and reproductive health for 2021 as mentioned in this paper, including advances and areas of controversy in male infertility, and a strength rating for each recommendation was included that was based either on a systematic review of the literature or consensus opinion from the expert panel, where applicable.
Testosterone supplementation and sexual function: a metaanalysis study
Corona Giovanni,Andrea M. Isidori,Aversa Antonio,Rastrelli Giulia,Vincenzo Rochira,Lenzi Andrea,Maggi Mario +6 more
TL;DR: Isidori et al. as mentioned in this paper performed a meta-analysis on the effect of testosterone supplementation on male sexual function and its synergism with the use of phosphodiesterase type 5 inhibitor (PDE5i).
Journal ArticleDOI
Severely low testosterone in males with COVID-19: A case-control study.
Andrea Salonia,Marina Pontillo,Paolo Capogrosso,Silvia Gregori,M. Tassara,Luca Boeri,Cristina Carenzi,Costantino Abbate,D. Cignoli,Anna Maria Ferrara,Walter Cazzaniga,Isaline Rowe,Giuseppe A. Ramirez,Cristina Tresoldi,Junaid Mushtaq,Massimo Locatelli,Luca Santoleri,Antonella Castagna,Alberto Zangrillo,Francesco De Cobelli,Moreno Tresoldi,Giovanni Landoni,Patrizia Rovere-Querini,Fabio Ciceri,Francesco Montorsi +24 more
TL;DR: In this article, the association between circulating androgens levels in a cohort of 286 symptomatic men with laboratory-confirmed CoV-2 infection status and secondary hypogonadism already at hospital admission was investigated.
Journal ArticleDOI
Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials
Shalender Bhasin,Susan S. Ellenberg,Thomas W. Storer,Shehzad Basaria,Marco Pahor,Alisa J. Stephens-Shields,Jane A. Cauley,Kristine E. Ensrud,John T. Farrar,David Cella,Alvin M. Matsumoto,Glenn R. Cunningham,Ronald S. Swerdloff,Christina Wang,Cora E. Lewis,Mark E. Molitch,Elizabeth Barrett-Connor,Jill P. Crandall,Xiaoling Hou,Peter Preston,Denise Cifelli,Peter J. Snyder,Thomas M. Gill +22 more
TL;DR: Men in the testosterone group were more likely to perceive improvement in their walking ability (PGIC) than men in the placebo group, both in all men in TTrials and in men enrolled in the PFT.
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