Broca's region: Novel organizational principles and multiple receptor mapping
Katrin Amunts,Katrin Amunts,Marianne Lenzen,Marianne Lenzen,Marianne Lenzen,Angela D. Friederici,Axel Schleicher,Patricia Morosan,Nicola Palomero-Gallagher,Karl Zilles,Karl Zilles +10 more
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TLDR
A novel map of Broca's language region is proposed based on transmitter receptor distributions as functionally relevant molecular markers that sheds new light on the relation between anatomy and functional segregation.Abstract:
There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M2 receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.read more
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The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
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References
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Journal ArticleDOI
Language within our grasp
TL;DR: It is proposed here that an observation/execution matching system provides a necessary bridge from'doing' to'communicating', as the link between actor and observer becomes a link between the sender and the receiver of each message.
Journal ArticleDOI
Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing
Mathieu Vigneau,Virginie Beaucousin,Pierre-Yves Hervé,Hugues Duffau,Fabrice Crivello,Olivier Houdé,Bernard Mazoyer,Bernard Mazoyer,Nathalie Tzourio-Mazoyer +8 more
TL;DR: A large-scale meta-analysis of language literature sheds light on the fine-scale functional architecture of the inferior frontal gyrus for phonological and semantic processing, the evidence for an elementary audio-motor loop involved in both comprehension and production of syllables, and the hypothesis that different working memory perception-actions loops are identifiable for the different language components.
Journal ArticleDOI
The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations.
TL;DR: It is concluded that, although there are several mechanisms through which one can understand the behaviour of other individuals, the parieto-frontal mechanism is the only one that allows an individual to understand the action of others 'from the inside' and gives the observer a first-person grasp of the motor goals and intentions of other Individuals.
Journal ArticleDOI
Functional MRI of Language: New Approaches to Understanding the Cortical Organization of Semantic Processing
TL;DR: Three lines of fMRI research into how the semantic system is organized in the adult brain are discussed, which broaden the understanding of how the brain stores, retrieves, and makes sense of semantic information and challenge some commonly held notions of functional modularity in the language system.