C. elegans in high-throughput drug discovery.
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TLDR
This review will outline the evolution of C. elegans-based drug screening, discuss the inherent challenges of using the organism, and highlight recent technological advances that have paved the way for future drug screens.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2014-04-20 and is currently open access. It has received 201 citations till now. The article focuses on the topics: Reverse pharmacology & Drug discovery.read more
Citations
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Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
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Anthelmintic Drug Discovery: Into the Future
TL;DR: The approaches and technologies in use to identify anthelmintics are reviewed and a number of drug discovery paradigms that may prove pivotal to the next half-century of anthel Mintic development are discussed.
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Developments in the tools and methodologies of synthetic biology.
TL;DR: A shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled, and tested as part of a biological design cycle.
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An enhanced C. elegans based platform for toxicity assessment.
TL;DR: A convenient, low cost assay utilising the nematode Caenorhabditis elegans to rapidly assess both acute toxicity and developmental and reproductive toxicity (DART) and the applicability of this assay for a range of chemicals with differing properties, including a modified exposure protocol for volatile or less soluble compounds is demonstrated.
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Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.
TL;DR: An automated microfluidic platform that enables high-content screening of various C. elegans disease models at the speed and cost of in vitro cell-based assays and the efficacy of FDA-approved drugs in improving the aggregation phenotype of the model is tested.
References
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Andrew Fire,SiQun Xu,Mary K. Montgomery,Steven A. Kostas,Steven A. Kostas,Samuel E. Driver,Craig C. Mello +6 more
TL;DR: To their surprise, it was found that double-stranded RNA was substantially more effective at producing interference than was either strand individually, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process.
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The genetics of caenorhabditis elegans
TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
Journal Article
The genetics of Caenorhabditis elegans.
TL;DR: Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
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Genome sequence of the nematode C-elegans: A platform for investigating biology
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A C. elegans mutant that lives twice as long as wild type
TL;DR: Finding that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type raises the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation.