C2-domains, structure and function of a universal ca2+-binding domain
Josep Rizo,Thomas C. Südhof +1 more
TLDR
This minireview will attempt to correlate the functional properties of C2-domains with their structures and represent a family of versatile protein modules with diverse functions.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-06-26 and is currently open access. It has received 803 citations till now. The article focuses on the topics: Domain (software engineering) & C2 domain.read more
Citations
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Synthesis and Function of 3-Phosphorylated Inositol Lipids
Bart Vanhaesebroeck,Sally J. Leevers,Khatereh Ahmadi,John F. Timms,Roy Katso,Paul C. Driscoll,Rudiger Woscholski,Peter J. Parker,Michael D. Waterfield +8 more
TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
Journal ArticleDOI
The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
David A. Six,Edward A. Dennis +1 more
TL;DR: This review updates the classification of the various PLA(2)'s now described in the literature, and expands or realignment of Groups VI, VII and VIII, as well as the addition of Group XIPLA(2) from plants.
Journal ArticleDOI
Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
Jie-Oh Lee,Haijuan Yang,Maria-Magdalena Georgescu,A. Di Cristofano,Tomohiko Maehama,Yigong Shi,Jack E. Dixon,Pier Paolo Pandolfi,Nikola P. Pavletich +8 more
TL;DR: The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but has an enlarged active site important for the accommodation of the phosphoinositide substrate and a C2 domain that may serve to productively position the catalytic domain on the membrane.
Journal ArticleDOI
Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C
TL;DR: It is realized that PLC-beta, -gamma, and -delta isoforms act in concert, each contributing to a specific aspect of the cellular response.
Journal ArticleDOI
Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy
Jing Liu,Masashi Aoki,Isabel Illa,Chenyan Wu,Michel Fardeau,Corrado Angelini,Carmen Serrano,J. Andoni Urtizberea,Fayçal Hentati,Mongi Ben Hamida,Saeed Bohlega,Edward J. Culper,Anthony A. Amato,K. Bossie,Joshua Oeltjen,Khemissa Bejaoui,Diane McKenna-Yasek,Betsy A. Hosler,Erwin Schurr,Kiichi Arahata,Pieter J. de Jong,Robert H. Brown +21 more
TL;DR: A 3-Mb P1-derived artificial chromosome contig spanning the MM candidate region clarified the order of genetic markers across the MM locus, provided five new polymorphic markers within it and narrowed the locus to approximately 2 Mb.
References
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Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.
Journal ArticleDOI
The synaptic vesicle cycle: a cascade of protein–protein interactions
TL;DR: A convergence of results now allows formulation of molecular models for key steps of the synaptic vesicle cycle, which may form the basis for a mechanistic understanding of higher neural function.
Journal ArticleDOI
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
James D. Clark,Lih-Ling Lin,Ronald W. Kriz,Chakkodabylu S. Ramesha,Lisa A. Sultzman,Alice Y. Lin,Nina Milona,John L. Knopf +7 more
TL;DR: The cloning and expression of a cDNA encoding a high molecular weight cytosolic phospholipase A2 (cPLA2) that has no detectable sequence homology with the secreted forms of PLA2 is reported and it is demonstrated that cPLA2 selectively cleaves arachidonic acid from natural membrane vesicles and translocates to membrane vESicles in response to physiologically relevant changes in free calcium.
Journal ArticleDOI
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.
Martin Geppert,Yukiko Goda,Robert E. Hammer,Cai Li,Thomas W. Rosahl,Charles F. Stevens,Thomas C. Südhof +6 more
TL;DR: It is proposed that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2-regulation of synchronous neurotransmitter release in hippocampal neurons and not essential for asynchronous or Ca(2+)-independent release.
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