Journal ArticleDOI
Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium
Nasim Babaknejad,Nasim Babaknejad,Somaye Bahrami,Ali Asghar Moshtaghie,Hashem Nayeri,Parvin Rajabi,Farhad Golshan Iranpour +6 more
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TLDR
It is suggested that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.Abstract:
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.read more
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Chronic exposure to multi-metals on testicular toxicity in rats.
TL;DR: While co-exposure to zinc with aluminum or copper produced reproductive toxicity the co-Exposure to all the three metals may lead to a significant testicular toxicity and these changes were related to increase in oxidative stress in rats.
Journal ArticleDOI
Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats.
TL;DR: In this article, the effects of zinc oxide nanoparticles (ZnO NPs) alone and in combination with lead acetate were evaluated in Wistar rats for 28 days, followed by the administration of α-lipoic acid (15 mg/kg, bwt) for the next 15 days.
Journal ArticleDOI
Protective Role of the Essential Trace Elements in the Obviation of Cadmium Toxicity: Glimpses of Mechanisms
TL;DR: In this article, the prototypical evidences of the protective effects of essential trace elements against Cd toxicity in animals and attempts to point out the underlying mechanisms are reported to be active.
Journal ArticleDOI
Physiological Roles of Red Carrot Methanolic Extract and Vitamin E to Abrogate Cadmium-Induced Oxidative Challenge and Apoptosis in Rat Testes: Involvement of the Bax/Bcl-2 Ratio.
Ahmed Abdel-Wahab,Kamel M.A. Hassanin,Ahmed A. Mahmoud,Walaa I. E. Abdel-Badeea,Abdel-Razik H. Abdel-Razik,Eman Zekry Attia,Usama Ramadan Abdelmohsen,Rabie L. Abdel Aziz,Agnieszka Najda,Ibtesam S. Alanazi,Khalaf F. Alsharif,Mohamed M. Abdel-Daim,Mohamed O. Mahmoud +12 more
TL;DR: In this article, the physiological impacts of either red carrot methanolic extract (RCME) or vitamin E (Vit. E), co-administrated with cadmium chloride (CdCl2) on rat testes, specifically those concerned with apoptosis and oxidative challenge, were investigated.
Journal ArticleDOI
Comprehensive Review of Cadmium Toxicity Mechanisms in Male Reproduction and Therapeutic Strategies.
TL;DR: In this paper, a review collects data from the literatures, discusses the underlying mechanisms of Cadmium-induced toxicity on male reproductive function, and summarizes evidence that may provide guidance for the treatment and prevention of Cd-induced male reproductive toxicity.
References
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Journal ArticleDOI
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