Journal ArticleDOI
Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium
Nasim Babaknejad,Nasim Babaknejad,Somaye Bahrami,Ali Asghar Moshtaghie,Hashem Nayeri,Parvin Rajabi,Farhad Golshan Iranpour +6 more
Reads0
Chats0
TLDR
It is suggested that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.Abstract:
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.read more
Citations
More filters
Journal ArticleDOI
Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review.
Md. Mostafizur Rahman,Kaniz Fatima Binte Hossain,Subrata Banik,Tajuddin Sikder,Mahmuda Akter,Serene Ezra Corpus Bondad,Shiblur Rahaman,Toshiyuki Hosokawa,Takeshi Saito,Masaaki Kurasaki +9 more
TL;DR: The critical protection mechanism/s of Se and Zn against Cd, Pb, As and Hg toxicity is demonstrated in a one by one manner to clarify the up-to-date findings and perspectives.
Journal ArticleDOI
The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.
TL;DR: The current review provides updated information about the protective actions of herbs and herbal extracts and their role as an effective strategy in reducing or preventing serious health problems and tissue damage in response to Cd toxicity.
Journal ArticleDOI
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
Xusheng Li,Zilan Yao,Dacheng Yang,Xinwei Jiang,Jianxia Sun,Lingmin Tian,Jun Hu,Biyu Wu,Weibin Bai +8 more
TL;DR: Anthocyanin cyanidin-3-O-glucoside showed partial resistance to Cd-induced histone modification during spermiogenesis and prevented oxidative damage of the DNA in the sperm nucleus, and mitigated the oxidative stress of testis to achieve the level coinciding with the control group.
Journal ArticleDOI
Cadmium as a testicular toxicant: A Review.
TL;DR: The present review summarizes the recent findings related to the Cd‐induced oxidative toxicity, apoptotic toxicity, steroidogenic toxicity, and spermatotoxicity, along with their possible mechanisms in testicular tissue of different animal species.
Journal ArticleDOI
Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice
TL;DR: Treatment with Se and LC has the highly synergistic and ameliorates the damaging effect of Cd on the testis through the elevation of the enzymatic antioxidant and diminish histopathological abnormalities and DNA damage.
References
More filters
Journal ArticleDOI
Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication
TL;DR: According to the available results, which indicate a protective role of Mg against Cd toxicity, it remains to be seen whether magnesium may influence the important unsolved problem of Cd intoxication therapy.
Journal ArticleDOI
Testicular oxidative stress
TL;DR: The findings suggest that varicocele may change the testicular oxidative status and may play a role in testicular dysfunction that causes infertility.
Journal ArticleDOI
The effect of oleanolic acid on sperm motion characteristics and fertility of male Wistar rats.
M. C. Mdhluli,G. van der Horst +1 more
TL;DR: Sperm motion analysed on the Sperm Motility Quantifier showed significant differences in linearity and wobble, but the curvilinear velocities were not significantly different among all the groups, and sperm motility patterns verified differences among kinematic parameters.
Journal ArticleDOI
Cadmium-induced inhibition of the growth and metastasis of human lung carcinoma xenografts: role of apoptosis
TL;DR: Cadmium can effectively reduce growth and progression of human lung carcinoma xenografts in a fashion that is probably independent of apoptosis, indicating that apoptotic pathways probably do not contribute to this anti-neoplastic effect.
Journal ArticleDOI
Effects of dietary zinc, manganese, and copper on tissue accumulation of cadmium by Japanese quail.
TL;DR: Zn nutrition appears to play an important role in protecting against dietary Cd absorption and reduced the Cd in the jejunum-ileum, liver, and kidney, respectively.