Journal ArticleDOI
Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium
Nasim Babaknejad,Nasim Babaknejad,Somaye Bahrami,Ali Asghar Moshtaghie,Hashem Nayeri,Parvin Rajabi,Farhad Golshan Iranpour +6 more
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TLDR
It is suggested that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.Abstract:
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.read more
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Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review.
Md. Mostafizur Rahman,Kaniz Fatima Binte Hossain,Subrata Banik,Tajuddin Sikder,Mahmuda Akter,Serene Ezra Corpus Bondad,Shiblur Rahaman,Toshiyuki Hosokawa,Takeshi Saito,Masaaki Kurasaki +9 more
TL;DR: The critical protection mechanism/s of Se and Zn against Cd, Pb, As and Hg toxicity is demonstrated in a one by one manner to clarify the up-to-date findings and perspectives.
Journal ArticleDOI
The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.
TL;DR: The current review provides updated information about the protective actions of herbs and herbal extracts and their role as an effective strategy in reducing or preventing serious health problems and tissue damage in response to Cd toxicity.
Journal ArticleDOI
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
Xusheng Li,Zilan Yao,Dacheng Yang,Xinwei Jiang,Jianxia Sun,Lingmin Tian,Jun Hu,Biyu Wu,Weibin Bai +8 more
TL;DR: Anthocyanin cyanidin-3-O-glucoside showed partial resistance to Cd-induced histone modification during spermiogenesis and prevented oxidative damage of the DNA in the sperm nucleus, and mitigated the oxidative stress of testis to achieve the level coinciding with the control group.
Journal ArticleDOI
Cadmium as a testicular toxicant: A Review.
TL;DR: The present review summarizes the recent findings related to the Cd‐induced oxidative toxicity, apoptotic toxicity, steroidogenic toxicity, and spermatotoxicity, along with their possible mechanisms in testicular tissue of different animal species.
Journal ArticleDOI
Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice
TL;DR: Treatment with Se and LC has the highly synergistic and ameliorates the damaging effect of Cd on the testis through the elevation of the enzymatic antioxidant and diminish histopathological abnormalities and DNA damage.
References
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Journal ArticleDOI
Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model
Laurent Noël,Céline Huynh-Delerme,Thierry Guérin,Hélène Huet,Jean-Marc Frémy,Martine Kolf-Clauw +5 more
TL;DR: Increasing cadmium in the culture medium resulted in a gradual and significant increase in the accumulation of zinc, and there was a significant decrease in manganese from 5 μmol Cd/l exposure, and no variation was observed with copper.
Journal ArticleDOI
Protective role of pectin against cadmium-induced testicular toxicity and oxidative stress in rats
TL;DR: Pectin can counteract the testicular toxicity and oxidative stress induced by cadmium and the effect was dose-dependent.
Journal ArticleDOI
Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke
Michele Kimie Sankako,Patrícia Carvalho Garcia,Renata C. Piffer,Bruna Dallaqua,Débora Cristina Damasceno,Oduvaldo C.M. Pereira +5 more
TL;DR: Exposure to cigarette smoke led to harmful effects on testicular function at least partially due to the exacerbation of oxidative stress, and zinc supplementation may be a promising addition to conventional treatments for male infertility related to smoking.
Journal ArticleDOI
FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice.
Lisa J. Martin,Haiyan Chen,Xiaoyan Liao,Hooman Allayee,Diana Mouhan Shih,Grace S. Lee,David N. Hovland,Wendie A. Robbins,Kay Carnes,Rex A. Hess,Aldons J. Lusis,Michael D. Collins +11 more
TL;DR: The protection afforded by FK506, found by the current study, indicated that CN is likely to be important in the mechanism of cadmium toxicity in the testis and possibly other organs.