Journal ArticleDOI
Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium
Nasim Babaknejad,Nasim Babaknejad,Somaye Bahrami,Ali Asghar Moshtaghie,Hashem Nayeri,Parvin Rajabi,Farhad Golshan Iranpour +6 more
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TLDR
It is suggested that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.Abstract:
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.read more
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Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review.
Md. Mostafizur Rahman,Kaniz Fatima Binte Hossain,Subrata Banik,Tajuddin Sikder,Mahmuda Akter,Serene Ezra Corpus Bondad,Shiblur Rahaman,Toshiyuki Hosokawa,Takeshi Saito,Masaaki Kurasaki +9 more
TL;DR: The critical protection mechanism/s of Se and Zn against Cd, Pb, As and Hg toxicity is demonstrated in a one by one manner to clarify the up-to-date findings and perspectives.
Journal ArticleDOI
The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.
TL;DR: The current review provides updated information about the protective actions of herbs and herbal extracts and their role as an effective strategy in reducing or preventing serious health problems and tissue damage in response to Cd toxicity.
Journal ArticleDOI
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
Xusheng Li,Zilan Yao,Dacheng Yang,Xinwei Jiang,Jianxia Sun,Lingmin Tian,Jun Hu,Biyu Wu,Weibin Bai +8 more
TL;DR: Anthocyanin cyanidin-3-O-glucoside showed partial resistance to Cd-induced histone modification during spermiogenesis and prevented oxidative damage of the DNA in the sperm nucleus, and mitigated the oxidative stress of testis to achieve the level coinciding with the control group.
Journal ArticleDOI
Cadmium as a testicular toxicant: A Review.
TL;DR: The present review summarizes the recent findings related to the Cd‐induced oxidative toxicity, apoptotic toxicity, steroidogenic toxicity, and spermatotoxicity, along with their possible mechanisms in testicular tissue of different animal species.
Journal ArticleDOI
Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice
TL;DR: Treatment with Se and LC has the highly synergistic and ameliorates the damaging effect of Cd on the testis through the elevation of the enzymatic antioxidant and diminish histopathological abnormalities and DNA damage.
References
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Journal ArticleDOI
Discovery of ZIP transporters that participate in cadmium damage to testis and kidney
TL;DR: Immunohistochemistry showed highly expressed ZIP8 protein in the renal proximal tubular epithelial apical surface, suggesting that ZIP8 participates in Cd-induced renal failure, and it is believed these two transporters function endogenously as Zn(2+)/HCO(3)(-) symporters important in combating inflammation and carrying out other physiological functions.
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Zinc protects renal function during cadmium intoxication in the rat
Grégory Jacquillet,Olivier Barbier,Marc Cougnon,Michel Tauc,María del Carmen Namorado,Dolores Martin,José L. Reyes,Philippe Poujeol +7 more
TL;DR: The results show that Cd2+ toxicity and cellular toxic mechanisms are complex, probably affecting both membrane transporters and tight junction proteins.
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Adverse effects of cadmium exposure on mouse sperm.
TL;DR: The effects of cadmium chloride exposure on sperm functional parameters were evaluated on eight-week-old ICR-CD1 male mice and resulted in an increased fraction of sperm with abnormal morphology, premature acrosome reaction and reduced motility.
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Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction
Mohammad Adil,Amit D. Kandhare,Gautami Dalvi,Pinaki Ghosh,Shivakumar Venkata,Kiran S. Raygude,Subhash L. Bodhankar +6 more
TL;DR: Berberine exerts renoprotective effects through its anti-oxidant, anti-inflammatory, and anti-apoptotic properties through the protective effect of berberine against GM-induced nephrotoxicity and possible underlying mechanisms.
Journal ArticleDOI
Reproductive effects of low acute doses of cadmium chloride in adult male rats.
TL;DR: Curve-linear regression analyses for the dose responsiveness of these parameters demonstrated that serum testosterone concentration initially decreased at a rate of 19%/mumol Cd/kg, respectively, and was the most sensitive to Cd exposure.