Journal ArticleDOI
Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium
Nasim Babaknejad,Nasim Babaknejad,Somaye Bahrami,Ali Asghar Moshtaghie,Hashem Nayeri,Parvin Rajabi,Farhad Golshan Iranpour +6 more
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TLDR
It is suggested that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.Abstract:
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.read more
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Journal ArticleDOI
Neuroendocrine effects of cadmium exposure on male reproductive functions.
Marcela Arteaga-Silva,Edith Arenas-Ríos,Herlinda Bonilla-Jaime,Pablo Damian-Matzumura,Ofelia Limón-Morales,Joel Hernández-Rodríguez,Darla Marquez-Aguiluz +6 more
TL;DR: This review analyses the state of the question regarding Cd's cellular and physiological mechanisms and the effects of this heavy metal on the neuroendocrine regulation of male reproduction.
Journal ArticleDOI
Counteracting effects of heavy metals and antioxidants on male fertility.
Soudeh Ghafouri-Fard,Hamed Shoorei,Mahdi Mohaqiq,Moloud Tahmasebi,Mohammad Seify,Mohammad Taheri +5 more
TL;DR: In this paper, the main outcomes of studies that assessed the counteracting impacts of heavy metal and antioxidants on male fertility were summarized, based on the provided data from animal studies, it seems rational to administrate appropriate antioxidants in persons who suffer from abnormal sperm parameters and infertility due to exposure to toxic elements.
Journal ArticleDOI
Aluminum Chloride-Induced Reproductive Toxicity in Rats: the Protective Role of Zinc Oxide Nanoparticles
Maha S. Lokman,Eman Ashraf,Rami B. Kassab,Rami B. Kassab,Ahmed E. Abdel Moneim,Nabil A. El-Yamany +5 more
TL;DR: In this paper, the effects of zinc oxide nanoparticle (ZnONP) treatment on Al-induced reproductive toxicity in rats were investigated, and the results suggest that ZnONPs could be used as an alternative agent to minimize the reproductive toxicity associated with Al exposure through its antioxidant, anti-inflammatory, antiapoptotic, and reproductive modulatory activities.
Journal ArticleDOI
Histopathological Findings of Testicular Tissue Following Cadmium Toxicity in Rats.
Saeedeh Shojaeepour,Shahriar Dabiri,Bahram Dabiri,Masoud Imani,Maryam Fekri Soofi Abadi,Fatemeh Hashemi +5 more
TL;DR: In this paper, the authors investigated the spectrum of histopathological changes in testicular tissue focusing on Sertoli cells in rats following Cd intoxication and found that Cd caused significant alterations in seminiferous tubules with varying effects on the patterns of spermatozoa production.
Journal ArticleDOI
Therapeutic effects of fluted pumpkin seeds on cadmium-induced testicular injury
TL;DR: In this paper, the effects of cadmium (Cd) on the testes of rats and the efficacy of fluted pumpkin seeds (FPS) supplementation were examined.
References
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