Journal ArticleDOI
Calcium-activated potassium channels.
TLDR
The biophysical properties of SK channels demonstrate that kinetic differences between Apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes, and Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.About:
This article is published in Current Opinion in Neurobiology.The article was published on 1998-06-01. It has received 996 citations till now. The article focuses on the topics: Voltage-gated ion channel & Calcium-activated potassium channel.read more
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Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
Interneurons of the neocortical inhibitory system.
TL;DR: This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.
Journal ArticleDOI
Molecular Diversity of K+ Channels
William A. Coetzee,Yimy Amarillo,Joanna C. Chiu,Alan Chow,David Lau,Tom McCormack,Herman Morena,Marcela S. Nadal,Ander Ozaita,David J. Pountney,Michael J. Saganich,Eleazar Vega-Saenz de Miera,Bernardo Rudy +12 more
TL;DR: This chapter attempts to give an overview of the different genes coding for K+ channel principal and accessory subunits and their genealogical relationships, and discusses the possible correlation of different principal sub units with native K+ channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression.
Journal ArticleDOI
On the cellular and network bases of epileptic seizures
TL;DR: Although epileptic syndromes and their causes are diverse, the cellular mechanisms of seizure generation appear to fall into only two categories: rhythmic or tonic "runaway" excitation or the synchronized and rhythmic interplay between excitatory and inhibitory neurons and membrane conductances.
Journal ArticleDOI
Ion channels and their functional role in vascular endothelium.
Bernd Nilius,Guillaume Droogmans +1 more
TL;DR: Evidence is presented for the involvement of ion channels in endothelial cell functions controlled by intracellular Ca(2+) signals, such as the production and release of many vasoactive factors, e.g., nitric oxide and PGI(2).
References
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Journal ArticleDOI
Biophysical and molecular mechanisms of shaker potassium channel inactivation
TL;DR: A region near the amino terminus with an important role in inactivation has been identified and the results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.
Journal ArticleDOI
Relaxation of arterial smooth muscle by calcium sparks
Mark T. Nelson,Heping Cheng,Michael Rubart,Luis Fernando Santana,Adrian D. Bonev,Harm J. Knot,W. J. Lederer +6 more
TL;DR: KCa channels activated by Ca2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of KCa channels.
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Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
Masaharu Noda,Shin Shimizu,Tsutomu Tanabe,Toshiyuki Takai,Toshiaki Kayano,Takayuki Ikeda,Hideo Takahashi,Hitoshi Nakayama,Yuichi Kanaoka,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,Michael A. Raftery,Tadaaki Hirose,Seiichi Inayama,Hidenori Hayashida,Takashi Miyata,Shosaku Numa +17 more
TL;DR: Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane.
Journal ArticleDOI
Small-conductance, calcium-activated potassium channels from mammalian brain.
M. Köhler,Birgit Hirschberg,Chris T. Bond,J M Kinzie,Neil V. Marrion,James Portland Maylie,John P. Adelman +6 more
TL;DR: Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain and formed into calcium-activated, voltage-independent potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.