Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics.
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TLDR
Ca2+-dependent mechanisms involved in the regulation of mitochondrial activity are summarized and some recent reports in which alterations in mitochondrial Ca2+ signalling have been associated with specific pathological conditions, such as neurodegeneration and cancer are discussed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-07-01 and is currently open access. It has received 211 citations till now. The article focuses on the topics: Intermembrane space & Mitochondrion.read more
Citations
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Selective neuronal vulnerability in Parkinson disease.
TL;DR: The evidence for and against the spreading LP model are discussed, as well as evidence that cell-autonomous factors govern both α-syn pathology and neuronal death.
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Obesity Cardiomyopathy: Evidence, Mechanisms and Therapeutic Implications.
TL;DR: In this article, a review of the evidence for obesity cardiomyopathy is presented, examining putative responsible mechanisms, and discusses therapeutic options for this disorder, which develops independent of hypertension, coronary heart disease, and other heart diseases.
Journal ArticleDOI
Fundamentals of Cellular Calcium Signaling: A Primer
Martin D. Bootman,Geert Bultynck +1 more
TL;DR: This primer discusses basic principles and mechanisms underlying cellular Ca2+ signaling andCa2+ homeostasis, with particular focus on Ca2- stores and Ca1+ transport across cellular membranes, as well as mechanisms by which Ca2+.
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How does the COVID-19 cause seizure and epilepsy in patients? The potential mechanisms.
TL;DR: Understanding the potential mechanisms is necessary to gain better insight into COVID-19 induced seizure pathogenesis and to design the correct treatment strategies to achieve appropriate treatment for seizure and epilepsy.
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Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems
TL;DR: In this paper, the authors discuss the current knowledge concerning the effects of hyperhomocysteine (Hcy) on mitochondrial homeostasis, including energy metabolism, mitochondrial apoptotic pathway, and mitochondrial dynamics.
References
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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
TL;DR: It is reported here that micromolar concentrations of Ins1,4,5P3 release Ca2+ from a nonmitochondrial intracellular Ca2- store in pancreatic acinar cells, and the results strongly suggest that this is the same Ca1+ store that is released by acetylcholine.
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Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses
Rosario Rizzuto,Paolo Pinton,Paolo Pinton,Walter A. Carrington,Walter A. Carrington,Frederic S. Fay,Frederic S. Fay,Kevin E. Fogarty,Kevin E. Fogarty,Lawrence M. Lifshitz,Lawrence M. Lifshitz,Richard A. Tuft,Richard A. Tuft,Tullio Pozzan,Tullio Pozzan +14 more
TL;DR: The spatial relation between mitochondria and endoplasmic reticulum in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins to emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.
Journal ArticleDOI
Fiber types in mammalian skeletal muscles.
TL;DR: Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors.
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Joshua M. Baughman,Fabiana Perocchi,Fabiana Perocchi,Hany S. Girgis,Hany S. Girgis,Molly Plovanich,Molly Plovanich,Casey A. Belcher-Timme,Casey A. Belcher-Timme,Yasemin Sancak,Yasemin Sancak,X. Robert Bao,X. Robert Bao,Laura Strittmatter,Laura Strittmatter,Olga Goldberger,Olga Goldberger,Roman L. Bogorad,Victor Koteliansky,Vamsi K. Mootha,Vamsi K. Mootha +20 more
TL;DR: Genome phylogenetic profiling, genome-wide RNA co-expression analysis and organelle-wide protein coexpression analysis are used to predict proteins functionally related to MICU1, establishing MCU as an essential component of the mitochondrial Ca2+ uniporter.
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Joshua M. Baughman,Fabiana Perocchi,Fabiana Perocchi,Hany S. Girgis,Hany S. Girgis,Molly Plovanich,Molly Plovanich,Casey A. Belcher-Timme,Casey A. Belcher-Timme,Yasemin Sancak,Yasemin Sancak,X. Robert Bao,X. Robert Bao,Laura Strittmatter,Laura Strittmatter,Olga Goldberger,Olga Goldberger,Roman L. Bogorad,Victor Koteliansky,Vamsi K. Mootha,Vamsi K. Mootha +20 more