Cancer cell adaptability: turning ribonucleoprotein granules into targets.
Margot Lavalée,Nicolas Curdy,Nicolas Curdy,Camille Laurent,Jean-Jacques Fournié,Jean-Jacques Fournié,Don-Marc Franchini,Don-Marc Franchini +7 more
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TLDR
The role of RNP granules in cancer, and how their composition and regulation might be used to elaborate therapeutic strategies, is discussed in this paper, where the authors focus on the role of SGs and P-bodies in cancer.Abstract:
Stress granules (SGs) and processing bodies (P-bodies) are membraneless cytoplasmic condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under physiological and pathological conditions, and are thereby involved in the regulation and maintenance of cellular integrity. During tumorigenesis, cancer cells use these granules to thrive, to adapt to the harsh conditions of the tumor microenvironment (TME), and to protect themselves from anticancer treatments. This ability to provide multiple outcomes not only makes RNP granules promising targets for cancer therapy but also emphasizes the need for more knowledge about the biology of these granules to achieve clinical use. In this review we focus on the role of RNP granules in cancer, and on how their composition and regulation might be used to elaborate therapeutic strategies.read more
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