Journal ArticleDOI
Cannabinoids in treatment-resistant epilepsy: A review.
TLDR
Open-label studies with 100mg/ml CBD have provided additional evidence of its efficacy along with an adequate safety profile in children and young adults with a spectrum of TREs and Phase 3 RCTs with Epidiolex support efficacy and adequate safety profiles for children with DS and LGS.About:
This article is published in Epilepsy & Behavior.The article was published on 2017-05-01. It has received 162 citations till now. The article focuses on the topics: Cannabis & Cannabidiol.read more
Citations
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Journal ArticleDOI
The level of evidence of medical marijuana use for treating disabilities: a scoping review
TL;DR: Overall, medical MJ does not improve the level of functioning, but it may improve the overall quality of life for people with disabilities, and has a clear lack of methodologically sound studies.
Journal ArticleDOI
CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways.
TL;DR: CB2R activation can induce neurons proliferation and survival through activation of ERK and p38 signaling pathways in nerve cells of a rat epilepsy model.
Journal ArticleDOI
A pharmacological characterization of Cannabis sativa chemovar extracts
Alykhan Devsi,Brett Kiyota,Theophile Ouellette,Andrew P. Hegle,Ricardo E. Rivera-Acevedo,Jasper Wong,Ying Dong,Michael K. Pugsley,Timothy Fung +8 more
TL;DR: Findings provide only limited support for the entourage hypothesis and further studies are necessary to characterize the nature of these pharmacological differences between cannabis chemovars and pure Δ9-THC.
Journal ArticleDOI
Medical Cannabis for Intractable Epilepsy in Childhood: A Review.
Bruria Ben-Zeev,Bruria Ben-Zeev +1 more
TL;DR: The current accumulated knowledge regarding artisanal cannabis and Epidiolex®, a United States Food and Drug Administration (FDA)-approved pure cannabidiol (CBD), in epilepsy management in pediatrics is discussed, by reviewing the literature and raising debate regarding further research directions.
Journal ArticleDOI
Automated gathering and analysis of cannabinoids treatment data
Rachita Chugh,Nidhi Chawla,Rochelle Maria Gracias,Jitender Singh Padda,Songyan Li,Minh Tuan Nguyen,Maria Spichkova,Nitin Mantri +7 more
TL;DR: An open source platform to integrate and analyse the cannabinoids research data gathered from academic publications, industrial and clinical trials as well as patients to provide evidence-based assistance for doctors, researchers and industry to identify the right cannabinoid profiles for various conditions.
References
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Journal ArticleDOI
Early Identification of Refractory Epilepsy
TL;DR: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Journal ArticleDOI
Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
Patrick Kwan,Alexis Arzimanoglou,Anne T. Berg,Martin J. Brodie,W. Allen Hauser,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Samuel Wiebe,Jacqueline A. French +9 more
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI
Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.
Orrin Devinsky,Maria Roberta Cilio,Helen Cross,Javier Fernández-Ruiz,Jacqueline A. French,Charlotte L Hill,Russell Katz,Vincenzo Di Marzo,Didier Jutras-Aswad,William George Notcutt,José Martínez-Orgado,Philip Robson,Brian G. Rohrback,Elizabeth A. Thiele,Benjamin J. Whalley,Daniel Friedman +15 more
TL;DR: CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic‐ischemic encephalopathy, however, data from well‐powered double‐blind randomized, controlled studies on the efficacy of pure CBD for any disorder is lacking.
Journal ArticleDOI
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
Orrin Devinsky,Eric D. Marsh,Daniel Friedman,Elizabeth A. Thiele,Linda Laux,Joseph Sullivan,Ian Miller,Robert Flamini,Angus Wilfong,Francis Filloux,Matthew Wong,Nicole Tilton,Patricia L. Bruno,Judith Bluvstein,Julie Hedlund,Rebecca M. Kamens,Jane Maclean,Srishti Nangia,Nilika S. Singhal,Carey A Wilson,Anup D. Patel,Maria Roberta Cilio +21 more
TL;DR: The findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
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