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Journal ArticleDOI

Cannabinoids in treatment-resistant epilepsy: A review.

Brooke K. O'Connell, +2 more
- 01 May 2017 - 
- Vol. 70, Iss: 70, pp 341-348
TLDR
Open-label studies with 100mg/ml CBD have provided additional evidence of its efficacy along with an adequate safety profile in children and young adults with a spectrum of TREs and Phase 3 RCTs with Epidiolex support efficacy and adequate safety profiles for children with DS and LGS.
About: 
This article is published in Epilepsy & Behavior.The article was published on 2017-05-01. It has received 162 citations till now. The article focuses on the topics: Cannabis & Cannabidiol.

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Citations
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Journal ArticleDOI

Evidence supporting the benefits of marijuana for Crohn’s disease and ulcerative colitis is extremely limited: a meta-analysis of the literatureEvidence supporting the benefits of marijuana for Crohn’s disease and ulcerative colitis is extremely limited: a meta-analysis of the literature

Anna Desmarais, +5 more
- 22 Jun 2020 - 
TL;DR: Data supporting the use of marijuana for the management of IBD are extremely limited and further well-designed studies are needed before any positive conclusions regarding marijuana use can be drawn.
Journal ArticleDOI

Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases.

Hebaallah Mamdouh Hashiesh, +7 more
- 15 Oct 2021 - 
TL;DR: In this paper, a comprehensive review comprehensively examined neuropharmacological activities of JWH133 in neurological disorders including neurodegenerative, neurodevelopmental and neuropsychiatric using synoptic tables and elucidated pharmacological mechanisms based on reported observations.
Journal ArticleDOI

Medical Marijuana in the Pediatric Population With Epilepsy-What You Should Know.

Michelle Markle, +1 more
- 01 Nov 2019 - 
TL;DR: The aim of this article is to arm providers with contemporary knowledge on the risks and benefits of MM use in the pediatric population with epilepsy, which may boost their skills and confidence in educating and advocating for children with seizures.
Journal ArticleDOI

Reversibility and Therapeutic Development for Neurodevelopmental Disorders, Insights from Genetic Animal Models.

P Megagiannis, +3 more
- 01 Sep 2022 - 
TL;DR: A review of recent neurobiological advances from experimental models of NDDs can be found in this article , where the expanding property of cutting-edge technologies, such as gene editing and AAV-mediated gene delivery, are leveraged in animal models for the therapeutic development of NDFs.
Journal ArticleDOI

Effects of Epidiolex® (Cannabidiol) on seizure-related emergency department visits and hospital admissions: A retrospective cohort study

Renad Abu-Sawwa, +3 more
- 01 Feb 2022 - 
TL;DR: In this paper , the potential impact of cannabidiol (CBD) on healthcare resource utilization and determine the effect of CBD on seizure-related emergency departments (ED) and hospital admissions in patients with epilepsy was evaluated.
References
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Journal ArticleDOI

Early Identification of Refractory Epilepsy

Patrick Kwan, +2 more
- 03 Feb 2000 - 
TL;DR: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Journal ArticleDOI

Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.

Patrick Kwan, +9 more
- 03 Nov 2009 - 
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI

Adverse Health Effects of Marijuana Use

Nora D. Volkow, +2 more
- 04 Jun 2014 - 
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Orrin Devinsky, +15 more
- 01 Jun 2014 - 
TL;DR: CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic‐ischemic encephalopathy, however, data from well‐powered double‐blind randomized, controlled studies on the efficacy of pure CBD for any disorder is lacking.
Journal ArticleDOI

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

Orrin Devinsky, +21 more
- 01 Mar 2016 - 
TL;DR: The findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
Related Papers (5)

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky, +8 more
- 24 May 2017 - 

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

Orrin Devinsky, +21 more
- 01 Mar 2016 - 

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

Elizabeth A. Thiele, +44 more
- 17 Mar 2018 - 

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Orrin Devinsky, +15 more
- 01 Jun 2014 - 

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.

Orrin Devinsky, +10 more
- 17 May 2018 -