Journal ArticleDOI
Cannabinoids in treatment-resistant epilepsy: A review.
TLDR
Open-label studies with 100mg/ml CBD have provided additional evidence of its efficacy along with an adequate safety profile in children and young adults with a spectrum of TREs and Phase 3 RCTs with Epidiolex support efficacy and adequate safety profiles for children with DS and LGS.About:
This article is published in Epilepsy & Behavior.The article was published on 2017-05-01. It has received 162 citations till now. The article focuses on the topics: Cannabis & Cannabidiol.read more
Citations
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Journal ArticleDOI
Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence
Emily Stockings,Dino Zagic,Gabrielle Campbell,Megan Weier,Wayne Hall,Suzanne Nielsen,Geoffrey K. Herkes,Michael Farrell,Louisa Degenhardt +8 more
TL;DR: Drug-grade CBD as adjuvant treatment in paediatric-onset drug-resistant epilepsy may reduce seizure frequency and quality of life; RCTs examining other syndromes and cannabinoids are needed.
Journal ArticleDOI
Medicinal Cannabis for Psychiatric Disorders: A Clinically-Focused Systematic Review
Jerome Sarris,Jerome Sarris,Justin Sinclair,Diana Karamacoska,Margaret Davidson,Joseph Firth,Joseph Firth +6 more
TL;DR: There is currently encouraging, albeit embryonic, evidence for medicinal cannabis in the treatment of a range of psychiatric disorders, however, clinicians need to be mindful of arange of prescriptive and occupational safety considerations, especially if initiating higher dose THC formulas.
Journal ArticleDOI
Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.
TL;DR: Evaluated the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy.
Journal ArticleDOI
Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle
Gustavo González-Cuevas,Gustavo González-Cuevas,Rémi Martin-Fardon,Tony M. Kerr,David G. Stouffer,Loren H. Parsons,Dana C. Hammell,Stan Lee Banks,Audra L. Stinchcomb,Friedbert Weiss +9 more
TL;DR: Proof of principle supporting potential of CBD in relapse prevention along two dimensions is provided: beneficial actions across several vulnerability states and long-lasting effects with only brief treatment.
Journal ArticleDOI
Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.
TL;DR: The results suggest that CBD may have beneficial effects on patient QOL, distinct from its seizure‐reducing effects; however, further studies in placebo‐controlled, double‐blind trials are necessary to confirm this finding.
References
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Journal ArticleDOI
Early Identification of Refractory Epilepsy
TL;DR: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Journal ArticleDOI
Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
Patrick Kwan,Alexis Arzimanoglou,Anne T. Berg,Martin J. Brodie,W. Allen Hauser,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Samuel Wiebe,Jacqueline A. French +9 more
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI
Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.
Orrin Devinsky,Maria Roberta Cilio,Helen Cross,Javier Fernández-Ruiz,Jacqueline A. French,Charlotte L Hill,Russell Katz,Vincenzo Di Marzo,Didier Jutras-Aswad,William George Notcutt,José Martínez-Orgado,Philip Robson,Brian G. Rohrback,Elizabeth A. Thiele,Benjamin J. Whalley,Daniel Friedman +15 more
TL;DR: CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic‐ischemic encephalopathy, however, data from well‐powered double‐blind randomized, controlled studies on the efficacy of pure CBD for any disorder is lacking.
Journal ArticleDOI
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
Orrin Devinsky,Eric D. Marsh,Daniel Friedman,Elizabeth A. Thiele,Linda Laux,Joseph Sullivan,Ian Miller,Robert Flamini,Angus Wilfong,Francis Filloux,Matthew Wong,Nicole Tilton,Patricia L. Bruno,Judith Bluvstein,Julie Hedlund,Rebecca M. Kamens,Jane Maclean,Srishti Nangia,Nilika S. Singhal,Carey A Wilson,Anup D. Patel,Maria Roberta Cilio +21 more
TL;DR: The findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
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