Journal ArticleDOI
Cannabinoids in treatment-resistant epilepsy: A review.
TLDR
Open-label studies with 100mg/ml CBD have provided additional evidence of its efficacy along with an adequate safety profile in children and young adults with a spectrum of TREs and Phase 3 RCTs with Epidiolex support efficacy and adequate safety profiles for children with DS and LGS.About:
This article is published in Epilepsy & Behavior.The article was published on 2017-05-01. It has received 162 citations till now. The article focuses on the topics: Cannabis & Cannabidiol.read more
Citations
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Journal ArticleDOI
Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses
Melissa M Lewis-Bakker,Yi Yang,Yi Yang,Rupali Vyawahare,Lakshmi P. Kotra,Lakshmi P. Kotra,Lakshmi P. Kotra +6 more
TL;DR: These processes must be subject to higher levels of scientific rigor as the patient population around the world are seeking the help of such extracts for various clinical conditions, and as medical cannabis industry is receiving acceptance in various countries.
Journal ArticleDOI
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment.
TL;DR: A review of phytochemistry and pharmacology of compounds present in Cannabis extracts in the context of the current knowledge about their synergistic actions and the implications of clinical use in the treatment of selected diseases is presented in this paper.
Journal ArticleDOI
Cannabinoid-Based Therapies and Brain Development: Potential Harmful Effect of Early Modulation of the Endocannabinoid System.
Patrícia Schonhofen,Patrícia Schonhofen,Ivi Juliana Bristot,Ivi Juliana Bristot,José Alexandre de Souza Crippa,Jaime Eduardo Cecílio Hallak,Antonio Waldo Zuardi,Richard B. Parsons,Fábio Klamt,Fábio Klamt +9 more
TL;DR: Since Cannabis extracts contain Δ9-tetrahydrocannabinol (Δ9-THC), it is considered that pure CBD is possibly safer for young patients, and CBD, as well as other natural and/or synthetic cannabinoids, should be studied in more detail as a therapeutic alternative to CBD-enriched Cannabis extracts for young Patients.
Book ChapterDOI
Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.
Victoria Golub,D. Samba Reddy +1 more
TL;DR: Overall, adjunct CBD has been found to be generally safe and effective for treatment-resistant seizures in children with severe early-onset epilepsy, and whether an add-on CBD is efficacious for the long-term treatment of various epilepsy and seizure types in adults being tested in various clinical trials.
Journal ArticleDOI
Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations.
TL;DR: Cannabis and its constituent cannabinoids are associated with risk of addiction, cognitive deficits, and mood/psychotic disorders, and preclinical and emerging clinical data suggest greater sensitivity to the effects of cannabinoids in women.
References
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Journal ArticleDOI
Early Identification of Refractory Epilepsy
TL;DR: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Journal ArticleDOI
Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
Patrick Kwan,Alexis Arzimanoglou,Anne T. Berg,Martin J. Brodie,W. Allen Hauser,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Samuel Wiebe,Jacqueline A. French +9 more
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI
Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.
Orrin Devinsky,Maria Roberta Cilio,Helen Cross,Javier Fernández-Ruiz,Jacqueline A. French,Charlotte L Hill,Russell Katz,Vincenzo Di Marzo,Didier Jutras-Aswad,William George Notcutt,José Martínez-Orgado,Philip Robson,Brian G. Rohrback,Elizabeth A. Thiele,Benjamin J. Whalley,Daniel Friedman +15 more
TL;DR: CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic‐ischemic encephalopathy, however, data from well‐powered double‐blind randomized, controlled studies on the efficacy of pure CBD for any disorder is lacking.
Journal ArticleDOI
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
Orrin Devinsky,Eric D. Marsh,Daniel Friedman,Elizabeth A. Thiele,Linda Laux,Joseph Sullivan,Ian Miller,Robert Flamini,Angus Wilfong,Francis Filloux,Matthew Wong,Nicole Tilton,Patricia L. Bruno,Judith Bluvstein,Julie Hedlund,Rebecca M. Kamens,Jane Maclean,Srishti Nangia,Nilika S. Singhal,Carey A Wilson,Anup D. Patel,Maria Roberta Cilio +21 more
TL;DR: The findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
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