Journal ArticleDOI
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Björn Dahlöf,Richard B. Devereux,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristiansson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel +14 more
TLDR
Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.About:
This article is published in The Lancet.The article was published on 2002-03-23. It has received 5380 citations till now. The article focuses on the topics: Angiotensin II & Atenolol.read more
Citations
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Journal ArticleDOI
Metabolic effect of telmisartan and losartan in hypertensive patients with metabolic syndrome.
Cristiana Vitale,Giuseppe Mercuro,Carlotta Castiglioni,Alessandra Cornoldi,Arianna Tulli,Massimo Fini,Maurizio Volterrani,Giuseppe M.C. Rosano +7 more
TL;DR: Telmisartan, an antihypertensive agent with evidence of partial peroxisome proliferator-activated receptor activity-gamma (PPARγ) activity, may improve insulin sensitivity and lipid profile in patients with metabolic syndrome and provide superior 24-hour blood pressure control.
Journal ArticleDOI
Rate and determinants of 10-year persistence with antihypertensive drugs
TL;DR: Long-term persistence in daily practice is low compared with persistence observed in randomized clinical trials and should be considered in the choice of a first-line antihypertensive agent.
Journal ArticleDOI
Gender differences in the effects of cardiovascular drugs
Juan Tamargo,Giuseppe M.C. Rosano,Giuseppe M.C. Rosano,Thomas Walther,J Duarte,Alexander Niessner,Juan Carlos Kaski,Claudio Ceconi,Heinz Drexel,Keld Kjeldsen,Keld Kjeldsen,Gianluigi Savarese,Christian Torp-Pedersen,Dan Atar,Basil S. Lewis,Stefan Agewall +15 more
TL;DR: Gender differences in the pharmacokinetics and pharmacodynamics of cardiovascular drugs are summarized and recommendations to close the gaps in the understanding of sex-specific differences in drug efficacy and safety are provided.
Journal ArticleDOI
Economic implications of evidence-based prescribing for hypertension: can better care cost less?
Michael A. Fischer,Jerry Avorn +1 more
TL;DR: Adherence to evidence-based prescribing guidelines for hypertension could result in substantial savings in prescription costs for elderly patients with hypertension that would amount to savings of about 1.2 billion dollars nationally.
Journal ArticleDOI
[Guidelines for the Diagnosis and Treatment of Chronic Heart Failure: executive summary (update 2005)]
Karl Swedberg,John G.F. Cleland,Henry J. Dargie,Helmut Drexler,Ferenc Follath,Michel Komajda,Luigi Tavazzi,Otto A. Smiseth,Antonello Gavazzi,Axel Haverich,Arno W. Hoes,Tiny Jaarsma,Jerzy Korewicki,Samuel Lévy,Cecilia Linde,Jose Lopez-Sendon,Markku S. Nieminen,Luc Pierard,Willem J. Remme +18 more
TL;DR: Guidelines for the Diagnosis and Treatment of Chronic Heart Failure : executive summary ( update 2005)]
References
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Journal ArticleDOI
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Lennart Hansson,Lars H Lindholm,Leo Niskanen,Jan Lanke,Thomas Hedner,Anders Niklason,Kimmo Luomanmäki,Björn Dahlöf,Ulf de Faire,Claes Mörlin,Bengt E. Karlberg,P. O. Wester,Jan-Erik Björck +12 more
TL;DR: Captopril and conventional treatment did not differ in efficacy in preventing cardiovascular morbidity and mortality and the difference in stroke risk was probably due to the lower levels of blood pressure obtained initially in previously treated patients randomised to conventional therapy.
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An updated coronary risk profile. A statement for health professionals.
TL;DR: Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Journal ArticleDOI
Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
TL;DR: Strong evidence of benefits of ACE inhibitors and calcium antagonists is provided by the overviews of placebo-controlled trials, and data from continuing trials of blood-pressure-lowering drugs will substantially increase the evidence available about any real differences that might exist between regimens.
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