Journal ArticleDOI
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Björn Dahlöf,Richard B. Devereux,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristiansson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel +14 more
TLDR
Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.About:
This article is published in The Lancet.The article was published on 2002-03-23. It has received 5380 citations till now. The article focuses on the topics: Angiotensin II & Atenolol.read more
Citations
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Journal ArticleDOI
Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
Journal ArticleDOI
Standards of Medical Care in Diabetes—2011
TL;DR: I. Screening and management of chronic complications in children and adolescents with type 1 diabetes i.e., screenings for type 2 diabetes and risk of future diabetes in adults, and strategy for improving diabetes care in the hospital, are outlined.
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Daniel W. Jones,Barry J. Materson +6 more
TL;DR: Aram V. Chobanian, MDGeorge L. Bakris, MDHenry R. Black, MDWilliam C. Cushman, MDLee A. Green, MD, MPHJoseph L. Izzo, Jr, MDDaniel W. Jones, MDBarry J. Materson, MBASuzanne Oparil, MDJackson T. Wright, Jr., MD, PhDEdward J. Roccella, PhD, MPHand the National High BloodPressure Education ProgramCoordinating Committee
Journal ArticleDOI
Treatment of Hypertension in Patients 80 Years of Age or Older
Nigel Beckett,Ruth Peters,Astrid E. Fletcher,Jan A. Staessen,Lisheng Liu,D Dumitrascu,Vassil Stoyanovsky,Riitta Antikainen,Yuri Nikitin,Craig S. Anderson,Alli Belhani,Françoise Forette,Chakravarthi Rajkumar,Lutgarde Thijs,Winston Banya,Christopher J. Bulpitt +15 more
TL;DR: The results provide evidence that antihypertensive treatment with indapamide (sustained release), with or without perindopril, in persons 80 years of age or older is beneficial.
Journal ArticleDOI
Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
Salim Yusuf,Marc A. Pfeffer,Karl Swedberg,Christopher B. Granger,Peter Held,John J.V. McMurray,Eric L. Michelson,Bertil Olofsson,Jan Östergren +8 more
TL;DR: Cedesartan has a moderate impact in preventing admissions for CHF among patients who have heart failure and LVEF higher than 40%.
References
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Journal ArticleDOI
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Lennart Hansson,Lars H Lindholm,Leo Niskanen,Jan Lanke,Thomas Hedner,Anders Niklason,Kimmo Luomanmäki,Björn Dahlöf,Ulf de Faire,Claes Mörlin,Bengt E. Karlberg,P. O. Wester,Jan-Erik Björck +12 more
TL;DR: Captopril and conventional treatment did not differ in efficacy in preventing cardiovascular morbidity and mortality and the difference in stroke risk was probably due to the lower levels of blood pressure obtained initially in previously treated patients randomised to conventional therapy.
Journal ArticleDOI
An updated coronary risk profile. A statement for health professionals.
TL;DR: Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Journal ArticleDOI
Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
TL;DR: Strong evidence of benefits of ACE inhibitors and calcium antagonists is provided by the overviews of placebo-controlled trials, and data from continuing trials of blood-pressure-lowering drugs will substantially increase the evidence available about any real differences that might exist between regimens.
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