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Journal ArticleDOI

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.

Björn Dahlöf, +14 more
- 23 Mar 2002 - 
- Vol. 359, Iss: 9311, pp 995-1003
TLDR
Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.
About: 
This article is published in The Lancet.The article was published on 2002-03-23. It has received 5380 citations till now. The article focuses on the topics: Angiotensin II & Atenolol.

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Citations
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Journal ArticleDOI

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.

Aram V. Chobanian, +10 more
- 21 May 2003 - 
TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
Journal ArticleDOI

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

Aram V. Chobanian, +10 more
- 01 Dec 2003 - 
TL;DR: In those older than age 50, systolic blood pressure of greater than 140 mm Hg is a more important cardiovascular disease (CVD) risk factor than diastolic BP, and hypertension will be controlled only if patients are motivated to stay on their treatment plan.
Journal ArticleDOI

2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

Giuseppe Mancia, +89 more
- 21 Jul 2013 - 
TL;DR: In this article, a randomized controlled trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly people was presented. But the authors did not discuss the effect of the combination therapy in patients living with systolic hypertension.
Journal ArticleDOI

2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

Giuseppe Mancia, +15 more
- 01 Jun 2007 - 
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Journal ArticleDOI

Inflammation in atherosclerosis

Peter Libby
- 19 Dec 2002 - 
TL;DR: The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering therapies and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets.
References
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Journal ArticleDOI

Echocardiographic left ventricular geometry in hypertensive patients with electrocardiographic left ventricular hypertrophy: The LIFE Study.

Richard B. Devereux, +13 more
- 01 Jan 2001 - 
TL;DR: To assess the prevalence of echocardiographic left ventricular hypertrophy (LVH) and concentric remodeling in hypertensive patients with electrocardiographic (ECG)-LVH and to estimate the costeffectiveness of eChocardiography and ECG for detection of LVH.
Journal ArticleDOI

Stroke is more common than myocardial infarction in hypertension: analysis based on 11 major randomized intervention trials.

Sverre E. Kjeldsen, +3 more
- 01 Jan 2001 - 
TL;DR: Stroke is more common than myocardial infarction in hypertension: analysis based on 11 major randomized intervention trials.
Journal ArticleDOI

Improved electrocardiographic detection of echocardiographic left ventricular hypertrophy: results of a correlated data base approach

James E. Norman, +1 more
- 01 Oct 1995 - 
TL;DR: Incorporation of obesity and age in ECG algorithms consistently improves their performance in the detection of hypertrophy and such ECG approaches should be used in clinical trials to assess the efficacy of antihypertensive treatment to effect regression of left ventricularhypertrophy.
Journal ArticleDOI

Efficacy and tolerability of losartan potassium and atenolol in patients with mild to moderate essential hypertension

Björn Dahlöf, +5 more
- 01 Jun 1995 - 
TL;DR: In conclusion, losartan was as efficacious as atenolol in blood pressure reduction, and was at least as well tolerated.
Journal ArticleDOI

Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics.

Pieter B.M.W.M. Timmermans
- 01 Jul 1999 - 
TL;DR: The predominant role of the AT1 receptor in mediating the pathophysiological role of Ang II underlies the effectiveness of this novel class of agents to lower arterial blood pressure, reduce pre- and afterload, inhibit sympathetic nervous system activity and prevent cardiovascular hypertrophy and cardiac failure induced by inappropriate control of the RAAS.
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Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

Salim Yusuf, +5 more
- 20 Jan 2000 - 

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)

Curt D. Furberg, +56 more
- 18 Dec 2002 - 

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.

Aram V. Chobanian, +10 more
- 21 May 2003 - 

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

Barry M. Brenner, +9 more
- 20 Sep 2001 - 

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

Edmond J Lewis, +9 more
- 20 Sep 2001 -