Journal ArticleDOI
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Björn Dahlöf,Richard B. Devereux,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristiansson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel +14 more
TLDR
Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.About:
This article is published in The Lancet.The article was published on 2002-03-23. It has received 5380 citations till now. The article focuses on the topics: Angiotensin II & Atenolol.read more
Citations
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Journal ArticleDOI
Changing Relationship of Blood Pressure with Mortality over Time among Hemodialysis Patients
Christine A. Stidley,William C. Hunt,Francesca Tentori,Darren W. Schmidt,Mark Rohrscheib,Susan Paine,Edward J. Bedrick,Klemens B. Meyer,H. Keith Johnson,Philip G. Zager +9 more
TL;DR: This study explores two hypotheses among hemodialysis patients: (1) the relationship between BP and mortality changes over time, and (2) mild to moderate hypertension is well tolerated.
Journal ArticleDOI
Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy: The life study
Stevo Julius,Michael H. Alderman,Gareth Beevers,Björn Dahlöf,Richard B. Devereux,Janice G. Douglas,Jonathan M. Edelman,Katherine E. Harris,Sverre E. Kjeldsen,Sverre E. Kjeldsen,Shawna D. Nesbitt,Otelio S. Randall,Jackson T. Wright +12 more
TL;DR: Results of the subanalysis are sufficient to generate the hypothesis that black patients with hypertension and LVH might not respond as favorably to losartan-based treatment as non-black patients with respect to cardiovascular outcomes, and do not support a recommendation forLosartan as a first-line treatment for this purpose.
Journal ArticleDOI
Contrast-induced Nephropathy.
TL;DR: The available treatment option makes prevention the corner stone of management, although dialysis may be required in some cases, and several biomarkers of tubular injury are under evaluation.
Journal ArticleDOI
Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations
Liviu Klein,Christopher M. O'Connor,Wendy A. Gattis,Manuela Zampino,Leonardo De Luca,Antonio Vitarelli,Francesco Fedele,Mihai Gheorghiade +7 more
TL;DR: Heart failure is a complex clinical syndrome resulting from any structural or functional cardiac disorder impairing the ability of the ventricles to fill with or eject blood, and certain therapies have been demonstrated to improve survival, decrease hospitalizations, and reduce symptoms.
Journal ArticleDOI
Obesity associated hypertension: new insights into mechanism.
TL;DR: A regulatory link between microvascular and perivascular adipose tissue inflammation and adipokine synthesis are provided to explain the mechanism of obesity-associated hypertension.
References
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Journal ArticleDOI
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Lennart Hansson,Lars H Lindholm,Leo Niskanen,Jan Lanke,Thomas Hedner,Anders Niklason,Kimmo Luomanmäki,Björn Dahlöf,Ulf de Faire,Claes Mörlin,Bengt E. Karlberg,P. O. Wester,Jan-Erik Björck +12 more
TL;DR: Captopril and conventional treatment did not differ in efficacy in preventing cardiovascular morbidity and mortality and the difference in stroke risk was probably due to the lower levels of blood pressure obtained initially in previously treated patients randomised to conventional therapy.
Journal ArticleDOI
An updated coronary risk profile. A statement for health professionals.
TL;DR: Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Journal ArticleDOI
Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
TL;DR: Strong evidence of benefits of ACE inhibitors and calcium antagonists is provided by the overviews of placebo-controlled trials, and data from continuing trials of blood-pressure-lowering drugs will substantially increase the evidence available about any real differences that might exist between regimens.
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