Journal ArticleDOI
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Björn Dahlöf,Richard B. Devereux,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristiansson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel +14 more
TLDR
Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.About:
This article is published in The Lancet.The article was published on 2002-03-23. It has received 5380 citations till now. The article focuses on the topics: Angiotensin II & Atenolol.read more
Citations
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Journal ArticleDOI
Arterial stiffness and cardiovascular therapy.
TL;DR: The present review is focused on a survey of different pharmacological therapeutic options for decreasing arterial stiffness, and the influence of several groups of drugs is described.
Journal ArticleDOI
Exceptional early blood pressure control rates: The ACCOMPLISH trial
Kenneth Jamerson,George L. Bakris,Björn Dahlöf,Bertram Pitt,Eric J. Velazquez,Jitendra Gupte,Martin Lefkowitz,Allen Hester,Victor Shi,Sverre E. Kjeldsen,William C. Cushman,Vasilios Papademetriou,Michael A. Weber +12 more
TL;DR: The ACCOMPLISH BP control rates are the highest of any multi‐national trial to date, and in this trial it is expedient and safe for both stage 1 and 2 hypertension.
Journal ArticleDOI
New Gender-Specific Partition Values for ECG Criteria of Left Ventricular Hypertrophy Recalibration Against Cardiac MRI
Khaled Alfakih,Kevin Walters,Tim R. Jones,John P. Ridgway,Alistair S. Hall,Mohan U. Sivananthan +5 more
TL;DR: The partition values for 4 different ECG LVH criteria, according to gender, are redefined, and it is found that they detect subjects with markedly elevated LVM index.
Journal ArticleDOI
Adiponectin and hypertension.
TL;DR: Clinical and experimental findings that examine the role of adiponectin in regulation of hypertension and vascular function and its beneficial effects on vascular disorders by directly affecting components of vascular tissue are discussed.
Journal ArticleDOI
Development and validation of stroke risk equation for Hong Kong Chinese patients with type 2 diabetes: the Hong Kong Diabetes Registry.
Xilin Yang,Wing-Yee So,Alice P.S. Kong,Chung-Shun Ho,Christopher W.K. Lam,Richard Stevens,Ramon R. Lyu,Donald D. Yin,Clive S. Cockram,Peter C.Y. Tong,Vivian C. W. Wong,Juliana C.N. Chan +11 more
TL;DR: Although the risk equation performed reasonably well in Chinese type 2 diabetic patients, external validation is required in other populations because the performance of the UKPDS stroke engine was suboptimal in this cohort.
References
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Journal ArticleDOI
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Lennart Hansson,Lars H Lindholm,Leo Niskanen,Jan Lanke,Thomas Hedner,Anders Niklason,Kimmo Luomanmäki,Björn Dahlöf,Ulf de Faire,Claes Mörlin,Bengt E. Karlberg,P. O. Wester,Jan-Erik Björck +12 more
TL;DR: Captopril and conventional treatment did not differ in efficacy in preventing cardiovascular morbidity and mortality and the difference in stroke risk was probably due to the lower levels of blood pressure obtained initially in previously treated patients randomised to conventional therapy.
Journal ArticleDOI
An updated coronary risk profile. A statement for health professionals.
TL;DR: Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Journal ArticleDOI
Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
TL;DR: Strong evidence of benefits of ACE inhibitors and calcium antagonists is provided by the overviews of placebo-controlled trials, and data from continuing trials of blood-pressure-lowering drugs will substantially increase the evidence available about any real differences that might exist between regimens.
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